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Hybrid Integrated Label-Free Chemical and Biological Sensors

Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, USA
Author to whom correspondence should be addressed.
Sensors 2014, 14(4), 5890-5928;
Received: 11 February 2014 / Revised: 10 March 2014 / Accepted: 14 March 2014 / Published: 26 March 2014
(This article belongs to the Special Issue Inorganic-Organic Hybrid Biological and Chemical Sensors)
PDF [1030 KB, uploaded 21 June 2014]


Label-free sensors based on electrical, mechanical and optical transduction methods have potential applications in numerous areas of society, ranging from healthcare to environmental monitoring. Initial research in the field focused on the development and optimization of various sensor platforms fabricated from a single material system, such as fiber-based optical sensors and silicon nanowire-based electrical sensors. However, more recent research efforts have explored designing sensors fabricated from multiple materials. For example, synthetic materials and/or biomaterials can also be added to the sensor to improve its response toward analytes of interest. By leveraging the properties of the different material systems, these hybrid sensing devices can have significantly improved performance over their single-material counterparts (better sensitivity, specificity, signal to noise, and/or detection limits). This review will briefly discuss some of the methods for creating these multi-material sensor platforms and the advances enabled by this design approach. View Full-Text
Keywords: sensor; active materials; chemical and biological detection sensor; active materials; chemical and biological detection

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Mehrabani, S.; Maker, A.J.; Armani, A.M. Hybrid Integrated Label-Free Chemical and Biological Sensors. Sensors 2014, 14, 5890-5928.

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