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Review

α-Hydroxyketone Synthesis and Sensing by Legionella and Vibrio

1
Competence Center for Applied Biotechnology and Molecular Medicine, University Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland
2
Max von Pettenkofer Institute, Ludwig-Maximilians University Munich, Pettenkoferstrasse 9a, 80336 Munich, Germany
*
Author to whom correspondence should be addressed.
Sensors 2012, 12(3), 2899-2919; https://doi.org/10.3390/s120302899
Received: 16 January 2012 / Revised: 23 February 2012 / Accepted: 23 February 2012 / Published: 2 March 2012
Bacteria synthesize and sense low molecular weight signaling molecules, termed autoinducers, to measure their population density and community complexity. One class of autoinducers, the α-hydroxyketones (AHKs), is produced and detected by the water-borne opportunistic pathogens Legionella pneumophila and Vibrio cholerae, which cause Legionnaires’ disease and cholera, respectively. The “Legionella quorum sensing” (lqs) or “cholera quorum sensing” (cqs) genes encode enzymes that produce and sense the AHK molecules “Legionella autoinducer-1” (LAI-1; 3-hydroxypentadecane-4-one) or cholera autoinducer-1 (CAI-1; 3-hydroxytridecane-4-one). AHK signaling regulates the virulence of L. pneumophila and V. cholerae, pathogen-host cell interactions, formation of biofilms or extracellular filaments, expression of a genomic “fitness island” and competence. Here, we outline the processes, wherein AHK signaling plays a role, and review recent insights into the function of proteins encoded by the lqs and cqs gene clusters. To this end, we will focus on the autoinducer synthases catalysing the biosynthesis of AHKs, on the cognate trans-membrane sensor kinases detecting the signals, and on components of the down-stream phosphorelay cascade that promote the transmission and integration of signaling events regulating gene expression. View Full-Text
Keywords: autoinducer synthase; cell-cell signaling; horizontal gene transfer; pathogen-host interactions; response regulator; quorum sensing; sensor kinase; two-component system; virulence autoinducer synthase; cell-cell signaling; horizontal gene transfer; pathogen-host interactions; response regulator; quorum sensing; sensor kinase; two-component system; virulence
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MDPI and ACS Style

Tiaden, A.; Hilbi, H. α-Hydroxyketone Synthesis and Sensing by Legionella and Vibrio. Sensors 2012, 12, 2899-2919. https://doi.org/10.3390/s120302899

AMA Style

Tiaden A, Hilbi H. α-Hydroxyketone Synthesis and Sensing by Legionella and Vibrio. Sensors. 2012; 12(3):2899-2919. https://doi.org/10.3390/s120302899

Chicago/Turabian Style

Tiaden, André, and Hubert Hilbi. 2012. "α-Hydroxyketone Synthesis and Sensing by Legionella and Vibrio" Sensors 12, no. 3: 2899-2919. https://doi.org/10.3390/s120302899

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