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Short Note

5-[4-(tert-Butyl)cyclohexylidene]-2-thioxothiazolidin-4-one

1
Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine
2
Department of Organic Chemistry and Pharmacy, Lesya Ukrainka Volyn National University, Volya Avenue 13, 43025 Lutsk, Ukraine
3
Department of Microbiology, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine
4
Department of Pharmaceutical Chemistry, National Pirogov Memorial Medical University, Pirogov 56, 21018 Vinnytsya, Ukraine
*
Author to whom correspondence should be addressed.
Academic Editor: Panayiotis A. Koutentis
Molbank 2021, 2021(4), M1281; https://doi.org/10.3390/M1281
Received: 29 July 2021 / Revised: 17 September 2021 / Accepted: 18 September 2021 / Published: 24 September 2021
The Knoevenagel reaction is an essential synthetic tool in the organic and medicinal chemistry of thiazolidin-4-one derivatives. In the present work, the application of ethylenediamine diacetate (EDDA) as an effective catalyst for the interaction of 2-thioxothiazolidin-4-one with 4-(tert-butyl)cyclohexanone is proposed. The structure of novel synthesized 5-[4-(tert-butyl)cyclohexylidene]-2-thioxothiazolidin-4-one (yield 61%) was confirmed by 1H-, 13C-NMR, LC-MS, IR, and UV spectra. Drug-like properties of the synthesized compound were evaluated in silico using the SwissAdme, and their potential antimicrobial activity against 15 strains of Gram-positive and Gram-negative bacteria as well as yeasts was evaluated in vitro. The synthesized compound possesses satisfactory drug-like parameters and promising antimicrobial properties and presents interest as a prospective intermediate for the forthcoming design of biologically active small molecules. View Full-Text
Keywords: Knoevenagel reaction; rhodanine; catalyst; ethylenediamine diacetate (EDDA); antimicrobial activity Knoevenagel reaction; rhodanine; catalyst; ethylenediamine diacetate (EDDA); antimicrobial activity
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MDPI and ACS Style

Holota, S.; Lozynskyi, A.; Konechnyi, Y.; Shepeta, Y.; Lesyk, R. 5-[4-(tert-Butyl)cyclohexylidene]-2-thioxothiazolidin-4-one. Molbank 2021, 2021, M1281. https://doi.org/10.3390/M1281

AMA Style

Holota S, Lozynskyi A, Konechnyi Y, Shepeta Y, Lesyk R. 5-[4-(tert-Butyl)cyclohexylidene]-2-thioxothiazolidin-4-one. Molbank. 2021; 2021(4):M1281. https://doi.org/10.3390/M1281

Chicago/Turabian Style

Holota, Serhii, Andrii Lozynskyi, Yulian Konechnyi, Yulia Shepeta, and Roman Lesyk. 2021. "5-[4-(tert-Butyl)cyclohexylidene]-2-thioxothiazolidin-4-one" Molbank 2021, no. 4: M1281. https://doi.org/10.3390/M1281

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