Immunogenetics of Multiple Sclerosis in Romanian Patients: Preliminary Data

Constantinescu, Alexandra Elena; Mărunțelu, Ion; Pleșa, Andreea; Sîrbu, Carmen Adella; Pleșa, Florentina Cristina; Constantinescu, Andreia Ioana; Constantinescu, Ileana

doi:10.3390/ijms26157628

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Immunogenetics of Multiple Sclerosis in Romanian Patients: Preliminary Data

by

Alexandra Elena Constantinescu

^1,2,

Ion Mărunțelu

^3,*

,

Andreea Pleșa

^1,4,

Carmen Adella Sîrbu

^4,5,6

,

Florentina Cristina Pleșa

^4,6,

Andreia Ioana Constantinescu

³ and

Ileana Constantinescu

^1,2,3,5

¹

Faculty of Medicine, ”Carol Davila” Medical University Bucharest, 020021 Bucharest, Romania

²

”Emil Palade” Center of Excellence for Young People in Scientific Research (EP-CEYR), Academy of Romanian Scientists, 030167 Bucharest, Romania

³

Fundeni Centre for Immunogenetics and Virology, Fundeni Clinical Institute, 022328 Bucharest, Romania

⁴

Neurology Department, Dr. Carol Davila Central Military Emergency University Hospital, 010825 Bucharest, Romania

⁵

Academy of Romanian Scientists, 030167 Bucharest, Romania

⁶

Clinical Neuroscience Department, University of Medicine and Pharmacy “Carol Davila”, 020021 Bucharest, Romania

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2025, 26(15), 7628; https://doi.org/10.3390/ijms26157628

Submission received: 22 May 2025 / Revised: 3 August 2025 / Accepted: 4 August 2025 / Published: 6 August 2025

(This article belongs to the Section Molecular Immunology)

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Abstract

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by the immune system attacking the central nervous system, leading to demyelination and neurodegeneration. This work investigates the relationship between specific human leukocyte antigen (HLA) polymorphisms and MS, aiming to reveal the immunogenetic background of this disease for more individualized management approaches. This study employed a case–control design, analyzing HLA allele frequencies in 179 MS patients and 200 control subjects using next-generation sequencing, The key findings indicate significant associations between several HLA Class I and II alleles and MS, including HLA-B*35:03:01:03, HLA-C*04:01:01:14, HLA-DRB1*15:01:01:26, and HLA-DQA1*05:05:01:02. These findings emphasize the critical role of HLA molecules in MS Romanian patients.

Keywords: HLA; genes; multiple sclerosis

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MDPI and ACS Style

Constantinescu, A.E.; Mărunțelu, I.; Pleșa, A.; Sîrbu, C.A.; Pleșa, F.C.; Constantinescu, A.I.; Constantinescu, I. Immunogenetics of Multiple Sclerosis in Romanian Patients: Preliminary Data. Int. J. Mol. Sci. 2025, 26, 7628. https://doi.org/10.3390/ijms26157628

AMA Style

Constantinescu AE, Mărunțelu I, Pleșa A, Sîrbu CA, Pleșa FC, Constantinescu AI, Constantinescu I. Immunogenetics of Multiple Sclerosis in Romanian Patients: Preliminary Data. International Journal of Molecular Sciences. 2025; 26(15):7628. https://doi.org/10.3390/ijms26157628

Chicago/Turabian Style

Constantinescu, Alexandra Elena, Ion Mărunțelu, Andreea Pleșa, Carmen Adella Sîrbu, Florentina Cristina Pleșa, Andreia Ioana Constantinescu, and Ileana Constantinescu. 2025. "Immunogenetics of Multiple Sclerosis in Romanian Patients: Preliminary Data" International Journal of Molecular Sciences 26, no. 15: 7628. https://doi.org/10.3390/ijms26157628

APA Style

Constantinescu, A. E., Mărunțelu, I., Pleșa, A., Sîrbu, C. A., Pleșa, F. C., Constantinescu, A. I., & Constantinescu, I. (2025). Immunogenetics of Multiple Sclerosis in Romanian Patients: Preliminary Data. International Journal of Molecular Sciences, 26(15), 7628. https://doi.org/10.3390/ijms26157628

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Immunogenetics of Multiple Sclerosis in Romanian Patients: Preliminary Data

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