Long-Term 5-HT1A Receptor Agonist NLX-112 Treatment Improves Functional Recovery After Spinal Cord Injury
Abstract
1. Introduction
2. Results
2.1. Two-Week Delayed NLX-112 Treatment Significantly Improves Locomotion After SCI in a Dose-Dependent Manner
2.2. NLX-112 Treatment Significantly Improves LUT Function at 8 Weeks After SCI
2.3. NLX-112 Treatment Significantly Improves Bladder Morphology After SCI
2.4. NLX-112 Treatment Significantly Decreases SCI-Upregulated Spinal 5-HT1A Receptors
3. Discussion
4. Materials and Methods
4.1. Animal Groups and Experimental Design
4.2. T8 Contusive SCI Surgery
4.3. The BBB Open Field Locomotion Test to Assess Hindlimb Locomotion
4.4. Awake Urodynamics and EUS EMG Recording
4.5. Quantification of CMG and EUS EMG Patterns
4.6. Analyses of Bladder Morphology
4.7. Immunohistochemistry for 5-HT1A Receptors and Analyses of Immunoreactivity
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Lin, C.-Y.; Li, K.; Gitchell, T.; Lee, Y.-S. Long-Term 5-HT1A Receptor Agonist NLX-112 Treatment Improves Functional Recovery After Spinal Cord Injury. Int. J. Mol. Sci. 2025, 26, 239. https://doi.org/10.3390/ijms26010239
Lin C-Y, Li K, Gitchell T, Lee Y-S. Long-Term 5-HT1A Receptor Agonist NLX-112 Treatment Improves Functional Recovery After Spinal Cord Injury. International Journal of Molecular Sciences. 2025; 26(1):239. https://doi.org/10.3390/ijms26010239
Chicago/Turabian StyleLin, Ching-Yi, Kevin Li, Thomas Gitchell, and Yu-Shang Lee. 2025. "Long-Term 5-HT1A Receptor Agonist NLX-112 Treatment Improves Functional Recovery After Spinal Cord Injury" International Journal of Molecular Sciences 26, no. 1: 239. https://doi.org/10.3390/ijms26010239
APA StyleLin, C.-Y., Li, K., Gitchell, T., & Lee, Y.-S. (2025). Long-Term 5-HT1A Receptor Agonist NLX-112 Treatment Improves Functional Recovery After Spinal Cord Injury. International Journal of Molecular Sciences, 26(1), 239. https://doi.org/10.3390/ijms26010239