Review Reports

Round 1

Reviewer 1 Report

Please open the attached file.

Comments for author File: Comments.pdf

Author Response

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Author Response File: Author Response.docx

Reviewer 2 Report

In this paper the authors present a novel murine model of chromium-induced allergic contact dermatitis. The manuscript is well written and structured. I have several minor suggestions.

In the Introduction Section, the authors should include more data on intraoral metal allergy, focusing on the one induced by chromium. An interesting article is doi: 10.3390/dj8030083

In the Discussion Section, the authors should discuss more about the toxic effects of chromium. It would be useful to include data from this article, doi: 10.5772/intechopen.90347

The authors mention the terms "a delayed-type hypersensitivity" and "type IV allergy". They should specify that type IV hypersensitivity reactions are also known as delayed-type hypersensitivity reactions.

Lines 267-270 "The stimulated inflammation at the inflammation site gradually decreased in the ICM group 7 days post challenge". Please rephrase it.

Author Response

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Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

The authors satisfactorily addressed all comments and suggestions. Thank you.