Review Reports

Round 1

Reviewer 1 Report

Dear authors,

In the following, I have mentioned several points that must be corrected.

In Abstract section,

- Please check your manuscript in terms of grammatical errors and typos.

-Please change the first two sentences of this section, and provide a more detailed and comprehensive introduction for this section.

- In Keywords section,

- Please mention all keywords in alphabetical order.

-Please try to provide each keyword up to two words.

In introduction section,

- If you can, please use the recently published papers as references in the introduction section (since 2018).

- Please try to extend this section and provide more information regarding the primary application of Corydalis saxicola Bunting (CSB).

- In my opinion, the introduction section has not a sufficient cohesion and coherence. Please add a more cohesive introduction regarding the primary available data about Corydalis saxicola Bunting (CSB).

-Please add a more detailed suggestion regarding the application of Corydalis saxicola Bunting (CSB) in the future.

-Please add a separate section as methods and explain your search strategy and search engines and also inclusion and exclusion criteria used in this review. 

- Please write the following sentence as a separate paragraph (also, please write the aim of your study in more detail),

"This review lays a foundation for further study on the pharmacological actions, mechanisms and clinical applications of CSB."

In Botanical distribution and description section,

- In the second paragraph, please add a figure to show the appearance characteristics of Corydalis saxicola Bunting (CSB) as explained in this section.

In Pharmacology section,

- In anticancer activity section, please add a Table regarding a summary of different cancer cells that Corydalis saxicola Bunting (CSB) shows anticancer activity against them and add a separate reference for each one.

-Please try to provide a conclusion and suggestion for each section.

In Antioxidant activity section,

-Please add a description about the IC50 meaning and DPPH method and then introduce different results of previous studies.

-In Isolated phytochemicals section, please add references for the first two sentences.

In Effects on the central nervous system section,

-Please add an introduction about the effects of different plant extracts on nerves system related diseases and then explain the obtained results about Corydalis saxicola Bunting (CSB).

In Anti-inflammatory activity section,

-Please add a summary about inflammatory system and mechanisms that regulate inflammation and then explain the obtained results about Corydalis saxicola Bunting (CSB).

In Analgesic effect section,

-Please add an introduction about the Analgesic effect and different plants that have Analgesic effects and then explain the obtained results about Corydalis saxicola Bunting (CSB).

In Antibacterial activity section,

-Please add an introduction for this section and explain MIC and MBC meanings, then provide the results of previous studies. If possible, summarize the previous results as a Table with separate references.

In Choleretic effects section,

-Please add an introduction about Choleretic effects and then explain the results of Corydalis saxicola Bunting (CSB).

In Clinical applications section,

-          In Icteric hepatitis section, please add references for the first two sentences.

-          In Hyperbilirubinemia section, please add references for the first 5 lines.

In Toxicity assessment section,

-          Line 3, “There are some studies on the toxicity of CSBTA…”, please add more than two refrences for this section.

Collectively, this is a comprehensive review about Corydalis saxicola Bunting (CSB); however, it needs some corrections and there are a lot of long and confusing sentences that should be revised to be more understandable.

 

Thank you so much for sharing your valuable review.

Author Response

Dear Editor:

I thank you and reviewers for the great efforts to help us in improving the quality of the manuscript (ijms-1926829). I have made point-by-point replies to your and reviewers’ specific criticisms, and revised the manuscript following the comments.

Author Response File: Author Response.docx

Reviewer 2 Report

After the revision of the manuscript entitled “Corydalis saxicola Bunting: A review of its traditional uses, phytochemistry, pharmacology, and clinical applications”, my comments are as follows:

1.         In the part of the traditional use: Is this plant used only in the traditional medicine of China? I think their traditional use is expanding in other countries. I suggest to do a thorough search in order to record other Tharapeutical uses in other countries.

2.         In the phytochemistry part: I do not think that the extracts of this plant are only alkaloids. There are other major molecules such as polyphenols, flavonoids, terpenes…. You have to look in this part. I consider it incomplete. To this end, I recommend to complete this part

3.         In the pharmacological part of CSB: The phytochemical compounds responsible for the pharmacological effect should not be indicated for each activity. I recommend you to shave all these phyto chemical data in a single part which is the phyto chemical part to come to conclusions on the phyto chemical profile of this plant. The general idea on the phytochemical profail of a plant is very interesting.

 

4.         Some abbreviations, it is necessary to indicate their meaning. Revise it's in all the maniscrit

Author Response

Dear Editor:

I thank you and reviewers for the great efforts to help us in improving the quality of the manuscript (ijms-1926829). I have made point-by-point replies to your and reviewers’ specific criticisms, and revised the manuscript following the comments.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Dear authors,

 

In my opinion, your manuscript is publishable as it stands. 

Reviewer 2 Report

the manuscript has been improved by the authors according to the recommendations given in previous revisions