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Article

Combined Modification of Fiber Materials by Enzymes and Metal Nanoparticles for Chemical and Biological Protection

1
Faculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, 119991 Moscow, Russia
2
N.M. Emanuel Institute of Biochemical Physics RAS, Kosygin str. 4, 119334 Moscow, Russia
3
Department of Physical Chemistry, National University of Science and Technology “MISIS”, Leninsky ave. 4, 119049 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Ylenia Zambito
Int. J. Mol. Sci. 2022, 23(3), 1359; https://doi.org/10.3390/ijms23031359
Received: 30 December 2021 / Revised: 13 January 2022 / Accepted: 24 January 2022 / Published: 25 January 2022
(This article belongs to the Collection Feature Papers in Materials Science)
To obtain fiber materials with pronounced chemical-biological protection, metal (Zn or Ta) nanoparticles were jointly applied with polyelectrolyte complexes of enzymes and polypeptides being their stabilizers. Computer modeling revealed the preferences between certain polyelectrolyte partners for N-acyl-homoserine lactone acylase and hexahistidine-tagged organophosphorus hydrolase (His6-OPH) possessing the quorum quenching (QQ) behavior with bacterial cells. The combinations of metal nanoparticles and enzymes appeared to function better as compared to the combinations of the same QQ-enzymes with antibiotics (polymyxins), making it possible to decrease the applied quantities by orders of magnitude while giving the same effect. The elimination of Gram-positive and Gram-negative bacterial cells from doubly modified fiber materials notably increased (up to 2.9-fold), whereas His6-OPH retained its hydrolytic activity in reaction with organophosphorus compounds (up to 74% of initially applied activity). Materials with the certain enzyme and Zn nanoparticles were more efficient against Bacillus subtilis cells (up to 2.1-fold), and Ta nanoparticles acted preferentially against Escherichia coli (up to 1.5-fold). Some materials were proved to be more suitable for combined modification by metal nanoparticles and His6-OPH complexes as antimicrobial protectants. View Full-Text
Keywords: fiber material; nanoparticle; antibiotic; enzyme; destruction; organophosphorus compound; chemical and biological protection; toxin fiber material; nanoparticle; antibiotic; enzyme; destruction; organophosphorus compound; chemical and biological protection; toxin
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MDPI and ACS Style

Lyagin, I.; Stepanov, N.; Frolov, G.; Efremenko, E. Combined Modification of Fiber Materials by Enzymes and Metal Nanoparticles for Chemical and Biological Protection. Int. J. Mol. Sci. 2022, 23, 1359. https://doi.org/10.3390/ijms23031359

AMA Style

Lyagin I, Stepanov N, Frolov G, Efremenko E. Combined Modification of Fiber Materials by Enzymes and Metal Nanoparticles for Chemical and Biological Protection. International Journal of Molecular Sciences. 2022; 23(3):1359. https://doi.org/10.3390/ijms23031359

Chicago/Turabian Style

Lyagin, Ilya, Nikolay Stepanov, George Frolov, and Elena Efremenko. 2022. "Combined Modification of Fiber Materials by Enzymes and Metal Nanoparticles for Chemical and Biological Protection" International Journal of Molecular Sciences 23, no. 3: 1359. https://doi.org/10.3390/ijms23031359

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