Biosensors for the Determination of SARS-CoV-2 Virus and Diagnosis of COVID-19 Infection

Drobysh, Maryia; Ramanaviciene, Almira; Viter, Roman; Chen, Chien-Fu; Samukaite-Bubniene, Urte; Ratautaite, Vilma; Ramanavicius, Arunas

doi:10.3390/ijms23020666

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Biosensors for the Determination of SARS-CoV-2 Virus and Diagnosis of COVID-19 Infection

^1,2

^3,4,*,

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Urte Samukaite-Bubniene

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Vilma Ratautaite

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and

Arunas Ramanavicius

^1,2,*

State Research Institute Center for Physical and Technological Sciences, Sauletekio Ave. 3, LT-10257 Vilnius, Lithuania

NanoTechnas—Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania

Center for Collective Use of Scientific Equipment, Sumy State University, Sanatornaya Str. 31, 40018 Sumy, Ukraine

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Institute of Atomic Physics and Spectroscopy, University of Latvia, Jelgavas Street 3, LV-1004 Riga, Latvia

⁵

Institute of Applied Mechanics, National Taiwan University 1, Sec. 4, Roosevelt Rd., Da’an Dist., Taipei 106, Taiwan

Authors to whom correspondence should be addressed.

Academic Editors: Joan Puig-Barberà, María Lourdes Guerrero, Anna Sominina, Svetlana V. Trushakova and F. Xavier López-Labrador

Int. J. Mol. Sci. 2022, 23(2), 666; https://doi.org/10.3390/ijms23020666

Received: 3 December 2021 / Revised: 29 December 2021 / Accepted: 3 January 2022 / Published: 8 January 2022

(This article belongs to the Topic Acute Respiratory Viruses Molecular Epidemiology)

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Abstract

Monitoring and tracking infection is required in order to reduce the spread of the coronavirus disease 2019 (COVID-19), induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To achieve this goal, the development and deployment of quick, accurate, and sensitive diagnostic methods are necessary. The determination of the SARS-CoV-2 virus is performed by biosensing devices, which vary according to detection methods and the biomarkers which are inducing/providing an analytical signal. RNA hybridisation, antigen-antibody affinity interaction, and a variety of other biological reactions are commonly used to generate analytical signals that can be precisely detected using electrochemical, electrochemiluminescence, optical, and other methodologies and transducers. Electrochemical biosensors, in particular, correspond to the current trend of bioanalytical process acceleration and simplification. Immunosensors are based on the determination of antigen-antibody interaction, which on some occasions can be determined in a label-free mode with sufficient sensitivity. View Full-Text

Keywords: COVID-19; SARS-CoV-2 virus; biosensors; electrochemical immunosensors; bioelectrochemistry; RNA analysis; antigen-antibody interaction; immune complex; immobilisation of biomolecules; molecularly imprinted polymers (MIPs)

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Drobysh, M.; Ramanaviciene, A.; Viter, R.; Chen, C.-F.; Samukaite-Bubniene, U.; Ratautaite, V.; Ramanavicius, A. Biosensors for the Determination of SARS-CoV-2 Virus and Diagnosis of COVID-19 Infection. Int. J. Mol. Sci. 2022, 23, 666. https://doi.org/10.3390/ijms23020666

AMA Style

Drobysh M, Ramanaviciene A, Viter R, Chen C-F, Samukaite-Bubniene U, Ratautaite V, Ramanavicius A. Biosensors for the Determination of SARS-CoV-2 Virus and Diagnosis of COVID-19 Infection. International Journal of Molecular Sciences. 2022; 23(2):666. https://doi.org/10.3390/ijms23020666

Chicago/Turabian Style

Drobysh, Maryia, Almira Ramanaviciene, Roman Viter, Chien-Fu Chen, Urte Samukaite-Bubniene, Vilma Ratautaite, and Arunas Ramanavicius. 2022. "Biosensors for the Determination of SARS-CoV-2 Virus and Diagnosis of COVID-19 Infection" International Journal of Molecular Sciences 23, no. 2: 666. https://doi.org/10.3390/ijms23020666

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Author Biographies

Maryia Drobysh

Ph.D. Student Maryia Drobysh studied chemistry at Belarusian State University and defended her diploma on the topic of “Effect of thymoquinone on the proliferative activity of glioma cells“ under the supervision of Doc. Dr. Semenkova. After graduation, she has been working in the field of radiopharmaceuticals manufacture for two years. Currently, she is a Ph.D. student in the Laboratory of Nanotechnology, Department of Functional Materials and Electronics, Center for Physical Sciences and Technology. At the moment Maryia is engaged in research related to the development of electrochemical immunosensors.

Almira Ramanaviciene

Prof. (HP) Dr. Almira Ramanaviciene is head of Nanotechnas—Center of Nanotechnology and Materials Science at the Faculty of Chemistry and Geosciences of Vilnius University, and head of Biosensor research groups at the State Research Institute Center for Innovative Medicine, Department of Immunology, Lithuania. She defended her PhD thesis in biomedicine in 2002 at the Institute of Immunology and Vilnius University. In 2008, she completed her habilitation procedure in Physical Sciences at Vilnius University. She has comprehensive experience in the field of biosensors and immunosensor development, focusing on nanostructures and different surface modification techniques, biofunctionalization methods, and various analyte detection options. Prof. Dr. Almira Ramanaviciene is an expert on international and national foundations. She has published more than 200 publications in Clarivate Analytics WoS referred journal (h index 46).

Roman Viter

Dr. Roman Viter received a MSc degree in physics at Odessa National I.I. Mechnikov University, Odessa, Ukraine in 2000. He got his PhD at Odessa National I.I. Mechnikov University, Odessa, Ukraine in 2011. Since 2014, he has obtained a position of Senior researcher at Institute of Atomic Physics and Spectroscopy at the University of Latvia. He is a coordinator of Latvian and H2020 projects. He is a supervisor of MSc, PhD, and postdoc projects. His main research is focused on development and characterization of photonic nanomaterials for applications in optical sensors and biosensors. He is also a member of Latvian Academy of science.

Urte Samukaite-Bubniene

Dr. Samukaite-Bubniene completed her doctorate in physical chemistry with a theoretical and practical combination of photoluminescence of enzyme/polymer systems for biosensor applications at Vilnius University in 2015. Topics in sensors, biofuel cells, bioelectronics, polymeric molecules, and nanotechnology are further developed in the Faculty of Chemistry and Geosciences, Department of Physical Chemistry. In parallel, after the investigations in the field of electrochemistry, she joined the department of Functional Materials and Electronics at the Center for Physical Sciences and Technology (FTMC) in 2018, where she has been working on smart membranes project and DNA-biosensors based on DNA-modifying enzymes. Knowledge about sensing systems led her to enter the R&D field and work with the industry. Since 2020, she has held a postdoctoral position at Vilnius Gediminas Technical University, Department of Mechatronics, Robotics and Digital Manufacturing.

Vilma Ratautaite

Dr. Vilma Ratautaite is a senior researcher at Center for Physical Sciences and Technology (FTMC). She received her Ph.D. in Chemistry in 2009 and obtained experience in the chemical synthesis of acrylamide-based sorbents suitable for capillary liquid chromatography and electrochromatography, capillary electrophoresis. She had a grant for a PostDoc position at Vilnius University, Faculty of Chemistry from 2011 to 2012. Her research areas are focused on electrochemical synthesis and evaluation of conducting polymers. During her post-doctoral research project, she worked with molecularly imprinted conducting polymers. She also has experience in the evaluation of electrochromic properties of conducting polymers.

Arunas Ramanavicius

Prof. Habil. Dr. Arunas Ramanavicius is a professor at Vilnius University, Lithuania. He is also leading the laboratory of NanoBioTechnology at Research Center of Physical Sciences and Technologies. He is a member of the Lithuanian Academy of Sciences. In 1998 he received PhD degree and in 2002, his doctor habilitus degree. Prof. A. Ramanavicius is serving as expert-evaluator in the Horizon 2020 program coordinated by European Commission and he is a technical advisor of many foundations located in European countries. He was a national coordinator of several nanotechnology related COST actions as well as an editorial board member of MDPI journals Materials; Sensors; and several other journals.

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