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Biosensors for the Determination of SARS-CoV-2 Virus and Diagnosis of COVID-19 Infection

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State Research Institute Center for Physical and Technological Sciences, Sauletekio Ave. 3, LT-10257 Vilnius, Lithuania
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NanoTechnas—Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania
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Center for Collective Use of Scientific Equipment, Sumy State University, Sanatornaya Str. 31, 40018 Sumy, Ukraine
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Institute of Atomic Physics and Spectroscopy, University of Latvia, Jelgavas Street 3, LV-1004 Riga, Latvia
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Institute of Applied Mechanics, National Taiwan University 1, Sec. 4, Roosevelt Rd., Da’an Dist., Taipei 106, Taiwan
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Authors to whom correspondence should be addressed.
Academic Editors: Joan Puig-Barberà, María Lourdes Guerrero, Anna Sominina, Svetlana V. Trushakova and F. Xavier López-Labrador
Int. J. Mol. Sci. 2022, 23(2), 666; https://doi.org/10.3390/ijms23020666
Received: 3 December 2021 / Revised: 29 December 2021 / Accepted: 3 January 2022 / Published: 8 January 2022
(This article belongs to the Topic Acute Respiratory Viruses Molecular Epidemiology)
Monitoring and tracking infection is required in order to reduce the spread of the coronavirus disease 2019 (COVID-19), induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To achieve this goal, the development and deployment of quick, accurate, and sensitive diagnostic methods are necessary. The determination of the SARS-CoV-2 virus is performed by biosensing devices, which vary according to detection methods and the biomarkers which are inducing/providing an analytical signal. RNA hybridisation, antigen-antibody affinity interaction, and a variety of other biological reactions are commonly used to generate analytical signals that can be precisely detected using electrochemical, electrochemiluminescence, optical, and other methodologies and transducers. Electrochemical biosensors, in particular, correspond to the current trend of bioanalytical process acceleration and simplification. Immunosensors are based on the determination of antigen-antibody interaction, which on some occasions can be determined in a label-free mode with sufficient sensitivity. View Full-Text
Keywords: COVID-19; SARS-CoV-2 virus; biosensors; electrochemical immunosensors; bioelectrochemistry; RNA analysis; antigen-antibody interaction; immune complex; immobilisation of biomolecules; molecularly imprinted polymers (MIPs) COVID-19; SARS-CoV-2 virus; biosensors; electrochemical immunosensors; bioelectrochemistry; RNA analysis; antigen-antibody interaction; immune complex; immobilisation of biomolecules; molecularly imprinted polymers (MIPs)
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MDPI and ACS Style

Drobysh, M.; Ramanaviciene, A.; Viter, R.; Chen, C.-F.; Samukaite-Bubniene, U.; Ratautaite, V.; Ramanavicius, A. Biosensors for the Determination of SARS-CoV-2 Virus and Diagnosis of COVID-19 Infection. Int. J. Mol. Sci. 2022, 23, 666. https://doi.org/10.3390/ijms23020666

AMA Style

Drobysh M, Ramanaviciene A, Viter R, Chen C-F, Samukaite-Bubniene U, Ratautaite V, Ramanavicius A. Biosensors for the Determination of SARS-CoV-2 Virus and Diagnosis of COVID-19 Infection. International Journal of Molecular Sciences. 2022; 23(2):666. https://doi.org/10.3390/ijms23020666

Chicago/Turabian Style

Drobysh, Maryia, Almira Ramanaviciene, Roman Viter, Chien-Fu Chen, Urte Samukaite-Bubniene, Vilma Ratautaite, and Arunas Ramanavicius. 2022. "Biosensors for the Determination of SARS-CoV-2 Virus and Diagnosis of COVID-19 Infection" International Journal of Molecular Sciences 23, no. 2: 666. https://doi.org/10.3390/ijms23020666

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