Green Tea Catechins: Nature’s Way of Preventing and Treating Cancer
Abstract
1. Introduction
2. Chemical Composition of Green Tea Catechins
3. Green Tea Catechins Health Beneficial Properties
3.1. Action Mechanism of Green Tea Catechins
3.2. Green Tea Catechins’ Anticancer Potential: In Vitro and In Vivo Studies
4. Signaling Pathways in Green Tea Catechins Anticancer Activity
5. Green Tea Catechins Anticancer Potential: Clinical Studies
6. Limitations of Using Green Tea Catechins as Anticancer Agents
7. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Food Stuff | Content | Reference |
---|---|---|
Green tea | 4.62 mg/100 mL | [23] |
Green tea (loose leaf form) | 56.5–205.0 mg/g dry tea | [24] |
Green tea (bagged leave form) | 54.3–153.0 mg/g dry tea | [24] |
Green tea (infusions) | 117 to 442 mg/L | [25] |
Apples, Fuji, raw, with skin | 1.93 mg/100 g edible portion | [26] |
Blackberries, raw (Rubus spp.) | 0.68 mg/100 g edible portion | [26] |
Cranberries, raw | 0.97 mg/100 g edible portion | [26] |
Nuts, pecans | 2.30 mg/100 g edible portion | [27] |
Tea, black, brewed, prepared with tap water | 9.36 mg/100 g edible portion | [27] |
Tea, fruit, dry | 415.0 mg/100 g edible portion | [27] |
Tea, green, brewed | 64.0 mg/100 g edible portion | [27] |
Tea, green, large leaf, Quingmao, dry leaves | 7380 mg/100 g edible portion | [27] |
Tea, white, dry leaves | 4245 mg/100 g edible portion | [27] |
Japanese green tea | 18.1–23.1 mg/g | [28] |
Long-jing tea | 32.9–35.5 mg/g | [28] |
Jasmine tea | 29.8–31.0 mg/g | [28] |
Sen-cha (tea bags) | 12.9–23.6 mg/g DM | [29] |
Carob flour | 109.46 mg/100 g edible portion | [27] |
Type of Cancer | Cancer Cell Line | Mechanism Involved | Reference |
---|---|---|---|
Breast cancer | MCF-7 | ↓Telomerase activity; ↓hTERT | [63] |
Lung cancer | A549 | ↑G0/G1 phase arrest | [64] |
Colon cancer | HCT116 | ↓TRAIL cell death | [65] |
Esophageal cancer | Eca109 & Ec9706 | ↓Bcl-2 protein expression; ↑Bax and caspase-3 protein expression | [66] |
Colorectal cancer | DLD-1 & SW480 | ↓Wnt/β-catenin pathway | [67] |
Thyroid cancer | 8505C | ↓EMT by regulating the TGF-β1/Smad signaling pathways | [68] |
Hepatocellular carcinoma | HCCLM6 | ↓MMP-2; ↓MMP-9; alteration in levels of FUBP1, HSPB1, CH60 and NPM proteins | [69] |
Type of Cancer | Study Model | Mechanism Involved | Reference |
---|---|---|---|
Pancreatic cancer | Balb/c mice | Inhibited tumor growth with ↓p-ERK, p-PI3K, p-AKT, and pFKHRL1/FOXO3a, | [70] |
Hepatocellular carcinoma | Rats | ↑DNA breakage; pro-oxidant effect | [54] |
Breast cancer | Balb/c mice | ↓VEGF | [71] |
Colon cancer | BALB/c mice | ↓HES1 and Notch2 induced the apoptosis | [72] |
Skin cancer | ICR mice | ↓TPA--induced DNA binding of NF--κB and CREB | [73] |
Lung cancer | Mice | ↓CSC-like characteristics by modulating the hsa-mir-485-5p/RXRα axis | [74] |
Esophageal carcinoma | BALB/c mice | Induced apoptosis and ↑ROS generation, ↓VEGF; ↑caspase-3 | [75] |
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Farhan, M. Green Tea Catechins: Nature’s Way of Preventing and Treating Cancer. Int. J. Mol. Sci. 2022, 23, 10713. https://doi.org/10.3390/ijms231810713
Farhan M. Green Tea Catechins: Nature’s Way of Preventing and Treating Cancer. International Journal of Molecular Sciences. 2022; 23(18):10713. https://doi.org/10.3390/ijms231810713
Chicago/Turabian StyleFarhan, Mohd. 2022. "Green Tea Catechins: Nature’s Way of Preventing and Treating Cancer" International Journal of Molecular Sciences 23, no. 18: 10713. https://doi.org/10.3390/ijms231810713
APA StyleFarhan, M. (2022). Green Tea Catechins: Nature’s Way of Preventing and Treating Cancer. International Journal of Molecular Sciences, 23(18), 10713. https://doi.org/10.3390/ijms231810713