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Review

The Effects of Acidosis on eNOS in the Systemic Vasculature: A Focus on Early Postnatal Ontogenesis

1
Department of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State University, 119234 Moscow, Russia
2
Laboratory of Exercise Physiology, State Research Center of the Russian Federation-Institute for Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia
3
Physiology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, 86159 Augsburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Tzong-Shyuan Lee and Maria Luisa Balestrieri
Int. J. Mol. Sci. 2022, 23(11), 5987; https://doi.org/10.3390/ijms23115987
Received: 25 April 2022 / Revised: 16 May 2022 / Accepted: 23 May 2022 / Published: 26 May 2022
(This article belongs to the Special Issue Nitric Oxide Synthases: Function and Regulation)
The activity of many vasomotor signaling pathways strongly depends on extracellular/intracellular pH. Nitric oxide (NO) is one of the most important vasodilators produced by the endothelium. In this review, we present evidence that in most vascular beds of mature mammalian organisms metabolic or respiratory acidosis increases functional endothelial NO-synthase (eNOS) activity, despite the observation that direct effects of low pH on eNOS enzymatic activity are inhibitory. This can be explained by the fact that acidosis increases the activity of signaling pathways that positively regulate eNOS activity. The role of NO in the regulation of vascular tone is greater in early postnatal ontogenesis compared to adulthood. Importantly, in early postnatal ontogenesis acidosis also augments functional eNOS activity and its contribution to the regulation of arterial contractility. Therefore, the effect of acidosis on total peripheral resistance in neonates may be stronger than in adults and can be one of the reasons for an undesirable decrease in blood pressure during neonatal asphyxia. The latter, however, should be proven in future studies. View Full-Text
Keywords: nitric oxide; eNOS; anticontractile influence; endothelium; acidosis; pH; early postnatal development; vasculature nitric oxide; eNOS; anticontractile influence; endothelium; acidosis; pH; early postnatal development; vasculature
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MDPI and ACS Style

Gaynullina, D.K.; Tarasova, O.S.; Shvetsova, A.A.; Borzykh, A.A.; Schubert, R. The Effects of Acidosis on eNOS in the Systemic Vasculature: A Focus on Early Postnatal Ontogenesis. Int. J. Mol. Sci. 2022, 23, 5987. https://doi.org/10.3390/ijms23115987

AMA Style

Gaynullina DK, Tarasova OS, Shvetsova AA, Borzykh AA, Schubert R. The Effects of Acidosis on eNOS in the Systemic Vasculature: A Focus on Early Postnatal Ontogenesis. International Journal of Molecular Sciences. 2022; 23(11):5987. https://doi.org/10.3390/ijms23115987

Chicago/Turabian Style

Gaynullina, Dina K., Olga S. Tarasova, Anastasia A. Shvetsova, Anna A. Borzykh, and Rudolf Schubert. 2022. "The Effects of Acidosis on eNOS in the Systemic Vasculature: A Focus on Early Postnatal Ontogenesis" International Journal of Molecular Sciences 23, no. 11: 5987. https://doi.org/10.3390/ijms23115987

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