Next Article in Journal
Antenna Protein Clustering In Vitro Unveiled by Fluorescence Correlation Spectroscopy
Next Article in Special Issue
Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells
Previous Article in Journal
A Hyaluronan and Platelet-Rich Plasma Hydrogel for Mesenchymal Stem Cell Delivery in the Intervertebral Disc: An Organ Culture Study
Previous Article in Special Issue
Nicotinamide Mononucleotide Potentiates Resistance to Biotrophic Invasion of Fungal Pathogens in Barley
Article

Nicotinamide Effectively Suppresses Fusarium Head Blight in Wheat Plants

1
Division of Life Science, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan
2
Biology Education, Faculty of Teacher Training and Education, Universitas Muhammadiyah Surakarta, Sukoharjo 57162, Indonesia
3
Institute for Gene Research, Advanced Science Research Center, Kanazawa University, Kanazawa 920-8640, Japan
4
Department of Agriculture, Ehime University, Ehime 790-8566, Japan
5
Division of Molecular and Cellular Biology, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Luigi Cattivelli 
Int. J. Mol. Sci. 2021, 22(6), 2968; https://doi.org/10.3390/ijms22062968
Received: 14 February 2021 / Revised: 5 March 2021 / Accepted: 5 March 2021 / Published: 15 March 2021
(This article belongs to the Special Issue Molecular Biology and Chemistry of Mycotoxins and Phytotoxins)
Pyridine nucleotides such as a nicotinamide adenine dinucleotide (NAD) are known as plant defense activators. We previously reported that nicotinamide mononucleotide (NMN) enhanced disease resistance against fungal pathogen Fusarium graminearum in barley and Arabidopsis. In this study, we reveal that the pretreatment of nicotinamide (NIM), which does not contain nucleotides, effectively suppresses disease development of Fusarium Head Blight (FHB) in wheat plants. Correspondingly, deoxynivalenol (DON) mycotoxin accumulation was also significantly decreased by NIM pretreatment. A metabolome analysis showed that several antioxidant and antifungal compounds such as trigonelline were significantly accumulated in the NIM-pretreated spikes after inoculation of F. graminearum. In addition, some metabolites involved in the DNA hypomethylation were accumulated in the NIM-pretreated spikes. On the other hand, fungal metabolites DON and ergosterol peroxide were significantly reduced by the NIM pretreatment. Since NIM is relative stable and inexpensive compared with NMN and NAD, it may be more useful for the control of symptoms of FHB and DON accumulation in wheat and other crops. View Full-Text
Keywords: nicotinamide; pyridine nucleotide; fusarium head blight; trichothecene mycotoxin; DNA hypomethylation; antifungal compound; metabolomics nicotinamide; pyridine nucleotide; fusarium head blight; trichothecene mycotoxin; DNA hypomethylation; antifungal compound; metabolomics
Show Figures

Figure 1

MDPI and ACS Style

Sidiq, Y.; Nakano, M.; Mori, Y.; Yaeno, T.; Kimura, M.; Nishiuchi, T. Nicotinamide Effectively Suppresses Fusarium Head Blight in Wheat Plants. Int. J. Mol. Sci. 2021, 22, 2968. https://doi.org/10.3390/ijms22062968

AMA Style

Sidiq Y, Nakano M, Mori Y, Yaeno T, Kimura M, Nishiuchi T. Nicotinamide Effectively Suppresses Fusarium Head Blight in Wheat Plants. International Journal of Molecular Sciences. 2021; 22(6):2968. https://doi.org/10.3390/ijms22062968

Chicago/Turabian Style

Sidiq, Yasir, Masataka Nakano, Yumi Mori, Takashi Yaeno, Makoto Kimura, and Takumi Nishiuchi. 2021. "Nicotinamide Effectively Suppresses Fusarium Head Blight in Wheat Plants" International Journal of Molecular Sciences 22, no. 6: 2968. https://doi.org/10.3390/ijms22062968

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop