Next Article in Journal
Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors
Next Article in Special Issue
Prolidase Stimulates Proliferation and Migration through Activation of the PI3K/Akt/mTOR Signaling Pathway in Human Keratinocytes
Previous Article in Journal
Melanocortin Receptor 4 (MC4R) Signaling System in Nile Tilapia
Review

Mesenchymal Stem Cell Secretome as an Emerging Cell-Free Alternative for Improving Wound Repair

1
Future Industries Institute, University of South Australia, Adelaide, SA 5000, Australia
2
Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7038; https://doi.org/10.3390/ijms21197038
Received: 3 September 2020 / Revised: 22 September 2020 / Accepted: 23 September 2020 / Published: 24 September 2020
(This article belongs to the Special Issue New Innovations in Wound Healing and Repair 2.0)
The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is currently of enormous interest. However, the broad translation of cell therapies into clinical use is hampered by their efficacy, safety, manufacturing and cost. MSCs release a broad repertoire of trophic factors and immunomodulatory cytokines, referred to as the MSC secretome, that has considerable potential for the treatment of cutaneous wounds as a cell-free therapy. In this review, we outline the current status of MSCs as a treatment for cutaneous wounds and introduce the potential of the MSC secretome as a cell-free alternative for wound repair. We discuss the challenges and provide insights and perspectives for the future development of the MSC secretome as well as identify its potential clinical translation into a therapeutic treatment. View Full-Text
Keywords: mesenchymal stem cells; secretome; wound healing mesenchymal stem cells; secretome; wound healing
Show Figures

Figure 1

MDPI and ACS Style

Ahangar, P.; Mills, S.J.; Cowin, A.J. Mesenchymal Stem Cell Secretome as an Emerging Cell-Free Alternative for Improving Wound Repair. Int. J. Mol. Sci. 2020, 21, 7038. https://doi.org/10.3390/ijms21197038

AMA Style

Ahangar P, Mills SJ, Cowin AJ. Mesenchymal Stem Cell Secretome as an Emerging Cell-Free Alternative for Improving Wound Repair. International Journal of Molecular Sciences. 2020; 21(19):7038. https://doi.org/10.3390/ijms21197038

Chicago/Turabian Style

Ahangar, Parinaz, Stuart J. Mills, and Allison J. Cowin 2020. "Mesenchymal Stem Cell Secretome as an Emerging Cell-Free Alternative for Improving Wound Repair" International Journal of Molecular Sciences 21, no. 19: 7038. https://doi.org/10.3390/ijms21197038

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop