CD38 and Anti-CD38 Monoclonal Antibodies in AL Amyloidosis: Targeting Plasma Cells and beyond
, Carla Naretto 1, Daniela Rossi 1, Michela Ferro 1, Antonella Barreca 2, Fabio Malavasi 3 and Simone Baldovino 1
Round 1
Reviewer 1 Report
The work makes a valuable contribution to timeous treatment of AL amyloidosis. It is comprehensive and well referenced and I would recommend publication. However, the English makes it difficult to read in certain instances for example, in the Introduction - where "specialists visit the patients"?
I think that where "in vivo" is mentioned, it should refer to clinical studies as in vivo usually refers to animal studies.
Table 1 is confusing as the information is duplicated.
Author Response
Reviewer #1:
R1.1: The work makes a valuable contribution to timeous treatment of AL amyloidosis. It is comprehensive and well referenced and I would recommend publication. However, the English makes it difficult to read in certain instances for example, in the Introduction - where "specialists visit the patients"?
Reply1.1. Thank you for your generally favorable comments. The manuscript has been edited by a native English speaker to improve the readability.
R1.2 I think that where "in vivo" is mentioned, it should refer to clinical studies as in vivo usually refers to animal studies.
Reply 1.2: the manuscript has been checked an amended as suggested when necessary.
R1.3. Table 1 is confusing as the information is duplicated.
Reply 1.3 To reduce redundancy, Table 1 has been omitted.
Reviewer 2 Report
This is a well written review. Covered all relevant and important aspects. Concluding remarks were appropriate.
Author Response
This is a well written review. Covered all relevant and important aspects. Concluding remarks were appropriate.
Reply2.1. Thank you for your favorable comments.
Reviewer 3 Report
The authors describe the comprehensive review of CD38 associated with AL amyloidosis. A couple of comments can be made to more improve the manuscript for readers.
Minor
- Results are explained well in accordance with lots of papers. However, each item feels quite fragmentary.
- There are a lot of misspelling and incomplete reference.
Author Response
Reviewer #3
Results are explained well in accordance with lots of papers. However, each item feels quite fragmentary. There are a lot of misspelling and incomplete reference.
Reply3.1. Thank you for your generally favorable comments. The manuscript has been edited by a native English speaker to improve the readability. References' list has been amended when necessary.
