Next Article in Journal
Downregulation of the Netrin-1 Receptor UNC5b Underlies Increased Placental Angiogenesis in Human Gestational Diabetes Mellitus
Next Article in Special Issue
The Effect of Molecular Weight on the Antibacterial Activity of N,N,N-Trimethyl Chitosan (TMC)
Previous Article in Journal
Exosomes and Hepatocellular Carcinoma: From Bench to Bedside
Previous Article in Special Issue
Rare-Earth-Doped Calcium Carbonate Exposed to X-ray Irradiation to Induce Reactive Oxygen Species for Tumor Treatment
Article Menu
Issue 6 (March-2) cover image

Export Article

Open AccessReview

Bioengineered Skin Intended for Skin Disease Modeling

1
Department of Biomechanical Engineering, Faculty of Mechanical, Maritime, and Materials Engineering, Delft University of Technology (TU Delft), Mekelweg 2, Delft 2628CD, The Netherlands
2
Product Development Group Zurich, Institute of Design, Material and Fabrication, Department of Mechanical and Process Engineering, Swiss Federal Institute of Technology (ETH Zurich), Leonhardstrasse 21, 8092 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(6), 1407; https://doi.org/10.3390/ijms20061407
Received: 12 February 2019 / Revised: 15 March 2019 / Accepted: 18 March 2019 / Published: 20 March 2019
(This article belongs to the Collection Feature Papers in Materials Science)
  |  
PDF [2637 KB, uploaded 27 March 2019]
  |  

Abstract

Clinical use of bioengineered skin in reconstructive surgery has been established for more than 30 years. The limitations and ethical considerations regarding the use of animal models have expanded the application of bioengineered skin in the areas of disease modeling and drug screening. These skin models should represent the anatomical and physiological traits of native skin for the efficient replication of normal and pathological skin conditions. In addition, reliability of such models is essential for the conduction of faithful, rapid, and large-scale studies. Therefore, research efforts are focused on automated fabrication methods to replace the traditional manual approaches. This report presents an overview of the skin models applicable to skin disease modeling along with their fabrication methods, and discusses the potential of the currently available options to conform and satisfy the demands for disease modeling and drug screening. View Full-Text
Keywords: bioengineered skin; biofabrication; skin disease modeling; standardization bioengineered skin; biofabrication; skin disease modeling; standardization
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Sarkiri, M.; Fox, S.C.; Fratila-Apachitei, L.E.; Zadpoor, A.A. Bioengineered Skin Intended for Skin Disease Modeling. Int. J. Mol. Sci. 2019, 20, 1407.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top