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Olive Tree Biophenols in Inflammatory Bowel Disease: When Bitter is Better

Department of Health Sciences, University of Catanzaro “Magna Graecia”, Viale Europa, 88100 Catanzaro, Italy
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Int. J. Mol. Sci. 2019, 20(6), 1390; https://doi.org/10.3390/ijms20061390
Received: 27 February 2019 / Revised: 15 March 2019 / Accepted: 15 March 2019 / Published: 20 March 2019
(This article belongs to the Special Issue Olive Bioactives, Nutraceuticals and Health)
The current therapeutic scenario for inflammatory bowel diseases (IBD) involves aminosalicylates, corticosteroids, and immunomodulators, but concerns regarding their safety profiles and high costs heavily impact their widespread use. In recent years, the beneficial effects thatbiophenols—from fruit and vegetables—have on human health have been investigated. The antioxidant and anti-inflammatory properties of phenolic fraction, from olive leaves and fruits, have been suggested, and a potential application in gut inflammation has been supported by in vitro and IBD-animal models studies. In the present review, we first introduced the potential therapeutic role of olive tree biophenolsin chronic inflammatory disease. Then, we aimed to describe their most interesting application for gut inflammation, as the results of basic science studies and animal experimental models. Finally, the potential role of olive tree biophenols in the setting of human IBD is discussed. View Full-Text
Keywords: inflammatory bowel disease; ulcerative colitis; Crohn’s disease; olive oil; olive leaves; biophenols; oleuropein; hydroxytyrosol; nutraceuticals inflammatory bowel disease; ulcerative colitis; Crohn’s disease; olive oil; olive leaves; biophenols; oleuropein; hydroxytyrosol; nutraceuticals
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Larussa, T.; Imeneo, M.; Luzza, F. Olive Tree Biophenols in Inflammatory Bowel Disease: When Bitter is Better. Int. J. Mol. Sci. 2019, 20, 1390.

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