Molecular-Level Interactions between Engineered Materials and Cells
by
Yoon-ha Jang 1,†, Xuelin Jin 2,†, Prabakaran Shankar 3,†
, Jung Heon Lee 3,*, Kyubong Jo 2,* and Kwang-il Lim 1,*
Yoon-ha Jang 1,†, Xuelin Jin 2,†, Prabakaran Shankar 3,†, Jung Heon Lee 3,*, Kyubong Jo 2,* and Kwang-il Lim 1,*
1
Department of Chemical and Biological Engineering, Sookmyung Women’s University, Seoul 04310, Korea
2
Department of Chemistry and Integrated Biotechnology, Sogang University, Seoul 04107, Korea
3
School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(17), 4142; https://doi.org/10.3390/ijms20174142
Received: 15 July 2019 / Revised: 19 August 2019 / Accepted: 21 August 2019 / Published: 25 August 2019
(This article belongs to the Special Issue Cell-Biomaterial Interaction 2019)
Various recent experimental observations indicate that growing cells on engineered materials can alter their physiology, function, and fate. This finding suggests that better molecular-level understanding of the interactions between cells and materials may guide the design and construction of sophisticated artificial substrates, potentially enabling control of cells for use in various biomedical applications. In this review, we introduce recent research results that shed light on molecular events and mechanisms involved in the interactions between cells and materials. We discuss the development of materials with distinct physical, chemical, and biological features, cellular sensing of the engineered materials, transfer of the sensing information to the cell nucleus, subsequent changes in physical and chemical states of genomic DNA, and finally the resulting cellular behavior changes. Ongoing efforts to advance materials engineering and the cell–material interface will eventually expand the cell-based applications in therapies and tissue regenerations.
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Keywords:
mechanotransduction; materials engineering; cell surface sensors; genome states; cellular responses
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Jang, Y.-H.; Jin, X.; Shankar, P.; Lee, J.H.; Jo, K.; Lim, K.-I. Molecular-Level Interactions between Engineered Materials and Cells. Int. J. Mol. Sci. 2019, 20, 4142.
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