Next Article in Journal
Cytosolic Copper Binding by a Bacterial Storage Protein and Interplay with Copper Efflux
Next Article in Special Issue
Recent Trends in Decellularized Extracellular Matrix Bioinks for 3D Printing: An Updated Review
Previous Article in Journal
PtrARF2.1 Is Involved in Regulation of Leaf Development and Lignin Biosynthesis in Poplar Trees
Previous Article in Special Issue
Functional Protein-Based Bioinspired Nanomaterials: From Coupled Proteins, Synthetic Approaches, Nanostructures to Applications
Open AccessReview

Molecular-Level Interactions between Engineered Materials and Cells

1
Department of Chemical and Biological Engineering, Sookmyung Women’s University, Seoul 04310, Korea
2
Department of Chemistry and Integrated Biotechnology, Sogang University, Seoul 04107, Korea
3
School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(17), 4142; https://doi.org/10.3390/ijms20174142
Received: 15 July 2019 / Revised: 19 August 2019 / Accepted: 21 August 2019 / Published: 25 August 2019
(This article belongs to the Special Issue Cell-Biomaterial Interaction 2019)
Various recent experimental observations indicate that growing cells on engineered materials can alter their physiology, function, and fate. This finding suggests that better molecular-level understanding of the interactions between cells and materials may guide the design and construction of sophisticated artificial substrates, potentially enabling control of cells for use in various biomedical applications. In this review, we introduce recent research results that shed light on molecular events and mechanisms involved in the interactions between cells and materials. We discuss the development of materials with distinct physical, chemical, and biological features, cellular sensing of the engineered materials, transfer of the sensing information to the cell nucleus, subsequent changes in physical and chemical states of genomic DNA, and finally the resulting cellular behavior changes. Ongoing efforts to advance materials engineering and the cell–material interface will eventually expand the cell-based applications in therapies and tissue regenerations. View Full-Text
Keywords: mechanotransduction; materials engineering; cell surface sensors; genome states; cellular responses mechanotransduction; materials engineering; cell surface sensors; genome states; cellular responses
Show Figures

Figure 1

MDPI and ACS Style

Jang, Y.-H.; Jin, X.; Shankar, P.; Lee, J.H.; Jo, K.; Lim, K.-I. Molecular-Level Interactions between Engineered Materials and Cells. Int. J. Mol. Sci. 2019, 20, 4142.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop