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Effect of Different Classes of Antihypertensive Drugs on Endothelial Function and Inflammation

Campus Centro Oeste Dona Lindu—Universidade Federal de São João del-Rei, Chanadour 400, Brazil
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Int. J. Mol. Sci. 2019, 20(14), 3458; https://doi.org/10.3390/ijms20143458
Received: 10 May 2019 / Revised: 5 June 2019 / Accepted: 6 June 2019 / Published: 14 July 2019
(This article belongs to the Special Issue Drug Discovery, Development and Regulatory Affairs)
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Abstract

Hypertension is characterized by structural and functional changes in blood vessels that travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction. Some antihypertensive drugs have been shown to improve endothelial function and reduce levels of inflammatory markers regardless of the effect of blood pressure lowering. Third-generation β-blockers, such as nebivolol and carvedilol, because they have additional properties, have been shown to improve endothelial function in patients with hypertension. Calcium channel antagonists, because they have antioxidant effects, may improve endothelial function and vascular inflammation.The Angiotensin Receptor Blocker (ARBs) are able to improve endothelial dysfunction and vascular inflammation in patients with hypertension and other cardiovascular diseases. Angiotensin converting enzyme (ACE) inhibitors have shown beneficial effects on endothelial function in patients with hypertension and other cardiovascular diseases, however there are few studies evaluating the effect of treatment with this class on the reduction of C-reactive protein (CRP) levels. Further studies are needed to assess whether treatment of endothelial dysfunction and vascular inflammation may improve the prognosis of patients with essential hypertension. View Full-Text
Keywords: hypertension; endothelial dysfunction; beta-blockers; calcium channel blockers; inhibitors of angiotensin converting enzyme and angiotensin receptor blockers hypertension; endothelial dysfunction; beta-blockers; calcium channel blockers; inhibitors of angiotensin converting enzyme and angiotensin receptor blockers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Silva, I.V.G.; de Figueiredo, R.C.; Rios, D.R.A. Effect of Different Classes of Antihypertensive Drugs on Endothelial Function and Inflammation. Int. J. Mol. Sci. 2019, 20, 3458.

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