Next Article in Journal
The Role of Ubiquitination in Regulating Embryonic Stem Cell Maintenance and Cancer Development
Next Article in Special Issue
Immunization of Rabbits with Recombinant Human Cytomegalovirus Trimeric versus Monomeric gH/gL Protein Elicits Markedly Higher Titers of Antibody and Neutralization Activity
Previous Article in Journal
The Role of gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice
Previous Article in Special Issue
Clinically Relevant Immune Responses against Cytomegalovirus: Implications for Precision Medicine
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 20
Issue 11
10.3390/ijms20112666
Review Report
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Cytomegalovirus Infections after Hematopoietic Stem Cell Transplantation: Current Status and Future Immunotherapy

Int. J. Mol. Sci. 2019, 20(11), 2666; https://doi.org/10.3390/ijms20112666
by Sung-Yeon Cho 1,2,3, Dong-Gun Lee 1,2,3,* and Hee-Je Kim 3,4,5,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2019, 20(11), 2666; https://doi.org/10.3390/ijms20112666
Submission received: 14 March 2019 / Revised: 19 April 2019 / Accepted: 28 May 2019 / Published: 30 May 2019
(This article belongs to the Special Issue Host-Cytomegalovirus Interactions: Pro- and Antiviral Key Factors Affecting CMV Infection Outcome or Therapeutic Approaches)

Round  1

Reviewer 1 Report

Need to improve quality of Fig 1.

In general , this article is well structured and developed.

All necessary items are precisely described .

Nevertheless , a certain inbalance on deepness and extension could be observed on item 6 which is, apparently, the main target of this paper. 

I'm recomending to improve this chapter.

Author Response

According to the reviewer's comment, we have revised the contents for immunotherapy (section 6 of the manuscript) with additional references.

The corrections include detailed strategies of adoptive T cell transfer to treat viral infection after HSCT with the history of the cell therapy (Line 326-349, Line 357-358, Line 367-377).  

The corrections are highlighted in the attatched file.

In addition, we have corrected the figure 1 as an additional figure file to improve the quality.

We hope the revised manuscript will better meet the requirement of the journal for publication.

We thank the editor and the reviewer of the IJMS once again.

Reviewer 2 Report

The review by Cho et al. nicely describe  the role of CMV infection/reactivation in HSCT and recent developments in new antiviral drugs and vaccines. However Major points are missing or not address adequate.

1.     The introduction part 1.1 is not necessary, because the main topic s CMV. On the other hand the part about CMV (1.2) is quite short. I would recommend to change the folding of the paras 3 and 4.

2.     Recently described resistances against leztermivir are not mentioned.

3.     Cellular based therapies to treat CMV-infections such as CD45RA-depletion as well as generation of T-cell lines or clones via expansion protocols. References mentioned here are not actual

Author Response

According to the reviewer's comment, we have revised the manuscript.

The changes are summerized below.

We have revised the introduction part with merging 1.1 and 1.2 into one section. (Line 35-71)

We have changed the folding of the paragraph 3 and paragraph 4 according to the reviewer's suggestion.

We have added descriptions for letermovir resistance. (Line 155-162)

We have modified the section 6 for immunotherapy including the contents for generation of T cell lines or clones via expansion protocols. (Line 326-349, Line 357-258, Line 367-377)

Round  2

Reviewer 1 Report

Modifications have clearly improved the manuscript.

Back to TopTop