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Int. J. Mol. Sci. 2018, 19(10), 3136;

The Role of the TGFβ Receptor Signaling Pathway in Adult Beta Cell Proliferation

Division of Pediatric Surgery, Department of Surgery, Children′s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Ave, Pittsburgh, PA 15224, USA
The Warren Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI 02903, USA
Author to whom correspondence should be addressed.
Received: 26 July 2018 / Revised: 9 October 2018 / Accepted: 10 October 2018 / Published: 12 October 2018
(This article belongs to the Special Issue TGF-Beta Super Family Signaling)
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Diabetes is a global epidemic and affects millions of individuals in the United States. Devising novel treatments for diabetes continues to be a great medical challenge. Postnatal beta cell growth or compensation is largely attributed to beta cell proliferation, which declines continuously with age. To boost beta cell proliferation to regenerate an adequate functional mass, there is a need to understand the signaling pathways that regulate beta cell proliferation for creating practical strategies to promote the process. Transforming growth factor β (TGFβ) belongs to a signaling superfamily that governs pancreatic development and the regeneration of beta cells after pancreatic diseases. TGFβ exerts its functions by activation of downstream Smad proteins and through its crosstalk with other pathways. Accumulating data demonstrate that the TGFβ receptor signaling pathway also participates in the control of beta cell proliferation. This review details the role of the TGFβ receptor signaling pathway in beta cell proliferation physiologically and in the pathogenesis of diabetes. View Full-Text
Keywords: diabetes; beta cell proliferation; Transforming growth factor β (TGFβ); SMAD7 diabetes; beta cell proliferation; Transforming growth factor β (TGFβ); SMAD7

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Jiang, Y.; Fischbach, S.; Xiao, X. The Role of the TGFβ Receptor Signaling Pathway in Adult Beta Cell Proliferation. Int. J. Mol. Sci. 2018, 19, 3136.

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