Next Article in Journal
Understanding the Inguinal Sinus in Sheep (Ovis aries)—Morphology, Secretion, and Expression of Progesterone, Estrogens, and Prolactin Receptors
Next Article in Special Issue
DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol
Previous Article in Journal
Glycosaminoglycans Regulate CXCR3 Ligands at Distinct Levels: Protection against Processing by Dipeptidyl Peptidase IV/CD26 and Interference with Receptor Signaling
Previous Article in Special Issue
The Effect of VPA on Increasing Radiosensitivity in Osteosarcoma Cells and Primary-Culture Cells from Chemical Carcinogen-Induced Breast Cancer in Rats
Open AccessReview

Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways

1
School of Allied Health Sciences, Faculty of Health & Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK
2
Material Measurement Laboratory, Biosystems and Biomaterials Division, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA
3
Material Measurement Laboratory, Biomolecular Measurement Division, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA
4
Swansea University Medical School, Institute of Life Science, Centre for NanoHealth, Swansea University Medical School, Wales, SA2 8PP, UK
*
Authors to whom correspondence should be addressed.
Current affiliation: Department of Pesticide Regulation, California Environmental Protection Agency, 1001 I Street, Sacramento, CA 95814, USA.
Int. J. Mol. Sci. 2017, 18(7), 1515; https://doi.org/10.3390/ijms18071515
Received: 13 June 2017 / Revised: 30 June 2017 / Accepted: 4 July 2017 / Published: 13 July 2017
(This article belongs to the Special Issue Chemically-Induced DNA Damage, Mutagenesis, and Cancer)
Some engineered nanomaterials (ENMs) may have the potential to cause damage to the genetic material in living systems. The mechanistic machinery functioning at the cellular/molecular level, in the form of DNA repair processes, has evolved to help circumvent DNA damage caused by exposure to a variety of foreign substances. Recent studies have contributed to our understanding of the various DNA damage repair pathways involved in the processing of DNA damage. However, the vast array of ENMs may present a relatively new challenge to the integrity of the human genome; therefore, the potential hazard posed by some ENMs necessitates the evaluation and understanding of ENM-induced DNA damage repair pathways. This review focuses on recent studies highlighting the differential regulation of DNA repair pathways, in response to a variety of ENMs, and discusses the various factors that dictate aberrant repair processes, including intracellular signalling, spatial interactions and ENM-specific responses. View Full-Text
Keywords: engineered nanomaterials; DNA damage; nanotoxicity; DNA repair proteins/genes; DNA repair pathways engineered nanomaterials; DNA damage; nanotoxicity; DNA repair proteins/genes; DNA repair pathways
Show Figures

Graphical abstract

MDPI and ACS Style

Singh, N.; Nelson, B.C.; Scanlan, L.D.; Coskun, E.; Jaruga, P.; Doak, S.H. Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways. Int. J. Mol. Sci. 2017, 18, 1515.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop