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The Ability of Extracellular Vesicles to Induce a Pro-Inflammatory Host Response

Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam 1012 WP, The Netherlands
Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Amsterdam 1006 AD, The Netherlands
Laboratory of Experimental Clinical Chemistry, Vesicle Observation Centre, Academic Medical Center, Amsterdam 1105 AZ, The Netherlands
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(6), 1285;
Received: 24 May 2017 / Revised: 12 June 2017 / Accepted: 13 June 2017 / Published: 16 June 2017
Extracellular vesicles (EVs) can modulate the host immune response, executing both pro- and anti-inflammatory effects. As EVs increasingly gain attention as potential carriers for targeted gene and drug delivery, knowledge on the effects of EVs on the host immune response is important. This review will focus on the ability of EVs to trigger a pro-inflammatory host response by activating target cells. The overall view is that EVs can augment an inflammatory response, thereby potentially contributing to organ injury. This pro-inflammatory potential of EVs may hamper its use for therapeutic drug delivery. Whether removal of EVs as a means to reduce a pro-inflammatory or pro-coagulant response during hyper-inflammatory conditions is beneficial remains to be determined. Prior to any proposed therapeutic application, there is a need for further studies on the role of EVs in physiology and pathophysiology using improved detection and characterization methods to elucidate the roles of EVs in inflammatory conditions. View Full-Text
Keywords: extracellular vesicles; inflammation; host response extracellular vesicles; inflammation; host response
MDPI and ACS Style

Van Hezel, M.E.; Nieuwland, R.; Van Bruggen, R.; Juffermans, N.P. The Ability of Extracellular Vesicles to Induce a Pro-Inflammatory Host Response. Int. J. Mol. Sci. 2017, 18, 1285.

AMA Style

Van Hezel ME, Nieuwland R, Van Bruggen R, Juffermans NP. The Ability of Extracellular Vesicles to Induce a Pro-Inflammatory Host Response. International Journal of Molecular Sciences. 2017; 18(6):1285.

Chicago/Turabian Style

Van Hezel, Maike E., Rienk Nieuwland, Robin Van Bruggen, and Nicole P. Juffermans 2017. "The Ability of Extracellular Vesicles to Induce a Pro-Inflammatory Host Response" International Journal of Molecular Sciences 18, no. 6: 1285.

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