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Int. J. Mol. Sci. 2017, 18(11), 2500; https://doi.org/10.3390/ijms18112500

A Mini-Review of the NADPH Oxidases in Vascular Dementia: Correlation with NOXs and Risk Factors for VaD

1,2
and
2,3,*
1
Center for Neuroscience Research, Institute of Biomedical Science & Technology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143701, Korea
2
Department of Medical Science, Konkuk University School of Medicine, 120 Neungdong-ro, Gwangjin-gu, Seoul 143701, Korea
3
Department of Rehabilitation Medicine, Konkuk University School of Medicine, 120 Neungdong-ro, Gwangjin-gu, Seoul 143701, Korea
*
Author to whom correspondence should be addressed.
Received: 30 September 2017 / Revised: 20 November 2017 / Accepted: 21 November 2017 / Published: 22 November 2017
(This article belongs to the Special Issue Oxidative Stress in Vascular Diseases)
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Abstract

Oxidative stress (OS) is one of the factors that cause dementia conditions such as Alzheimer’s disease and vascular dementia (VaD). In the pathogenesis of VaD, OS is associated with risk factors that include increased age, hypertension, and stroke. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are a molecular source of reactive oxygen species (ROS). According to recent studies, inhibition of NOX activity can reduce cognitive impairment in animal models of VaD. In this article, we review the evidence linking cognitive impairment with NOX-dependent OS, including the vascular NOX and non-vascular NOX systems, in VaD. View Full-Text
Keywords: oxidative stress (OS); vascular dementia (VaD); reactive oxygen species (ROS); NADPH oxidases (NOX); cognitive impairment; risk factors oxidative stress (OS); vascular dementia (VaD); reactive oxygen species (ROS); NADPH oxidases (NOX); cognitive impairment; risk factors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Choi, D.-H.; Lee, J. A Mini-Review of the NADPH Oxidases in Vascular Dementia: Correlation with NOXs and Risk Factors for VaD. Int. J. Mol. Sci. 2017, 18, 2500.

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