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Int. J. Mol. Sci. 2016, 17(12), 2022;

Peripheral Inflammatory Parameters in Late-Life Depression: A Systematic Review

Biomedical Research Centre in Mental Health Network (CIBERSAM), BioAraba, Health Research Institute, Araba University Hospital, 01004 Vitoria, Spain
Psychobiology Department, National Distance Education University (UNED), 01008 Vitoria, Spain
Gregorio Marañón University General Hospital, 28007 Madrid, Spain
Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, UK
Community Pharmacist, Getxo, 48992 Vizcaya, Spain
Department of Psychiatry, Showa University School of Medicine, Tokyo 157-8577, Japan
RSMB-CSM Uribe, 48990 Algorta-Getxo, Spain
Neurosciences Department, University of the Basque Country, 48940 Vizcaya, Spain
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 1 September 2016 / Revised: 3 November 2016 / Accepted: 16 November 2016 / Published: 2 December 2016
(This article belongs to the Collection Feature Annual Reviews in Molecular Sciences)
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Depressive disorders appear relatively frequently in older patients, and therefore represent an important disease burden worldwide. Given the high levels of inflammatory parameters found in depressed elderly patients, the “inflammaging” hypothesis is gaining strength. In this systematic review, we summarize current evidence regarding the relationship between inflammatory parameters and late-life depression, with a unique focus on longitudinal studies to guarantee temporality. According to the data summarized in this review, the levels of some proinflammatory parameters—especially interleukin (IL)-8, IL-6, and tumor necrosis factor (TNF)-α—could serve as biomarkers for the future development of depressive symptoms in elderly patients. Proinflammatory cytokines seem to be associated with the future development of clinically significant depression, irrespective of baseline scores, thus indicating that inflammation temporally precedes and increases depression risk. As insufficient research has been conducted in this field, further prospective studies are clearly warranted. View Full-Text
Keywords: inflammation; aging; depression; late-life inflammation; aging; depression; late-life

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Martínez-Cengotitabengoa, M.; Carrascón, L.; O’Brien, J.T.; Díaz-Gutiérrez, M.-J.; Bermúdez-Ampudia, C.; Sanada, K.; Arrasate, M.; González-Pinto, A. Peripheral Inflammatory Parameters in Late-Life Depression: A Systematic Review. Int. J. Mol. Sci. 2016, 17, 2022.

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