MiRNAs and LincRNAs: Could They Be Considered as Biomarkers in Colorectal Cancer?
Abstract
:1. Introduction
2. miRNAs and lincRNA Mechanism of Action
3. miRNAs, lincRNA and Cancer
4. miRNA Expression in CRC
5. ncRNA as Regulator of Tumor Hallmarkers and Vogelstein’s Model of CRC Pathogenesis
6. miRNA and Chemoresistance
7. SNPs and miRNA
8. miRNAs as Predictive and Prognostic Biomarkers in CRC
9. miRNAs as “One Plus” Potential Cancer Therapeutic Targets
10. Summary
References
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miRNA | Dysregulation | Clinical-related phenotypes | Reference |
---|---|---|---|
Let-7g | Upregulated in CRC | Higher level associated with poor S-1 response | [93] |
miR-18a | Upregulated in CRC | Higher level associated with poor overall survival | [106] |
miR-21 | Upregulated in adenoma, CRC, and liver metastasis tissue | Higher level associated with lymph node positivity, metastasis; poor survival, poor therapeutic outcomes, rapid recurrence; shorter disease-free interval | [80,105] |
miR-31 | Upregulated in CRC | Higher level associated with higher TNM stages and local invasion | [61,105,108] |
miR-106a | Upregulated in colon cancer | Higher level associated with longer disease-free survival and overall survival | [80] |
miR-143 | Downregulated in colon cancer and liver metastasis tissue | Lower level associated with larger tumor size and longer disease-free interval | [105,106,108] |
miR-145 | Downregulated in CRC | Lower level associated with larger tumor size; related with tumor location | [105,106,108] |
miR-181b | Upregulated in CRC | Higher level associated with poor S-1 response | [93] |
miR-320 | Downregulated in MSS tumor | Lower level associated with shorter progression-free survival | [103] |
miR-498 | Downregulated in MSS tumor | Lower level associated with shorter progression-free survival | [103] |
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
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Zarate, R.; Boni, V.; Bandres, E.; Garcia-Foncillas, J. MiRNAs and LincRNAs: Could They Be Considered as Biomarkers in Colorectal Cancer? Int. J. Mol. Sci. 2012, 13, 840-865. https://doi.org/10.3390/ijms13010840
Zarate R, Boni V, Bandres E, Garcia-Foncillas J. MiRNAs and LincRNAs: Could They Be Considered as Biomarkers in Colorectal Cancer? International Journal of Molecular Sciences. 2012; 13(1):840-865. https://doi.org/10.3390/ijms13010840
Chicago/Turabian StyleZarate, Ruth, Valentina Boni, Eva Bandres, and Jesús Garcia-Foncillas. 2012. "MiRNAs and LincRNAs: Could They Be Considered as Biomarkers in Colorectal Cancer?" International Journal of Molecular Sciences 13, no. 1: 840-865. https://doi.org/10.3390/ijms13010840