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Molecules, Volume 4, Issue 11 (November 1999) – 12 articles , Pages 320-337, Articles M116-M124

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31 KiB  
Article
Fast Solvent-free Alkylation of Amides and Lactams under Microwave Irradiation
by Dariusz Bogdal
Molecules 1999, 4(11), 333-337; https://doi.org/10.3390/41100333 - 25 Nov 1999
Cited by 35 | Viewed by 10080
Abstract
N-Substituted amides and lactams are rapidly N-alkylated under solvent-free phase-transfer catalytic conditions using microwaves. Full article
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Scheme 1

89 KiB  
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4,5-Dihydro-3-(4-chlorophenyl)-5-decylisoxazole
by Bruce A. Hathaway and Ryan A. Mueller
Molecules 1999, 4(11), M124; https://doi.org/10.3390/M124 - 23 Nov 1999
Viewed by 2365
Abstract
To a solution of 4-chlorobenzaldehyde oxime (0.40g) in CH2Cl2 (10 mL) in a large test-tube were added 1.0 mL of 1-dodecene and 3 drops of triethylamine. Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
91 KiB  
Short Note
3a,4,5,6,7,8,9,9a-Octahydro-3-(4-chlorophenyl)cyclooct[d]isoxazole
by Bruce A. Hathaway, Forest G. Peltan, Ryan A. Mueller and Ryan M. Redfearn
Molecules 1999, 4(11), M123; https://doi.org/10.3390/M123 - 23 Nov 1999
Viewed by 3243
Abstract
To a solution of 4-chlorobenzaldehyde oxime (0.40g ) in CH2Cl2 (10 mL) in a large test-tube were added 1.0 mL of cyclooctene and 3 drops of triethylamine.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
90 KiB  
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3a,4,5,6,7,8,8a-Heptahydro-3-(4-chlorophenyl)cyclohept[d]isoxazole
by Bruce A. Hathaway and Ryan A. Mueller
Molecules 1999, 4(11), M122; https://doi.org/10.3390/M122 - 23 Nov 1999
Viewed by 2549
Abstract
To a solution of 4-chlorobenzaldehyde oxime ( 0.40g) in CH2Cl2 (10 mL) in a large test-tube were added 1.0 mL of cycloheptene and 3 drops of triethylamine.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
90 KiB  
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3a,4,5,6,7,8,9,10,11,12,13,13a-Dodecahydro-3-(4-chlorophenyl)cyclododeca[d]isoxazole
by Bruce A. Hathaway and Ryan A. Mueller
Molecules 1999, 4(11), M121; https://doi.org/10.3390/M121 - 23 Nov 1999
Viewed by 2490
Abstract
To a solution of 4-chlorobenzaldehyde oxime (0.40g) in CH2Cl2 (10 mL) in a large test-tube were added 1.0 mL of cyclododecene and 3 drops of triethylamine.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
90 KiB  
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4-{[3-cyano-4-(methoxymethyl)-6-methyl-2-pyridinyl]oxy}benzoic acid
by Yelena Kaigorodova, Vladimir Vasilin and Gennady Krapivin
Molecules 1999, 4(11), M120; https://doi.org/10.3390/M120 - 23 Nov 1999
Viewed by 2749
Abstract
4-{[3-cyano-4-(methoxymethyl)-6-methyl-2-pyridinyl]oxy}benzoic acid 3 was prepared by the reaction of the 2-chloro-3-cyanopyridine 1 with 4-hydroxybenzoic acid 2 using a literature procedure [1].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
88 KiB  
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3-Cyano-2-cyanomethylthio-4-methoxymethyl-6-methylpyridine
by Yelena Kaigorodova, Vladimir Vasilin and Gennady Krapivin
Molecules 1999, 4(11), M119; https://doi.org/10.3390/M119 - 23 Nov 1999
Viewed by 2707
Abstract
2-Cyanomethylthiopyridine (2) was prepared by the reaction of the pyridinethione 1 with chloroacetonitrile using literature procedures [1, 2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
90 KiB  
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Methyl (2E,4E)-5-Anilino-4-(methoxycarbonyl)penta-2,4-dienoate
by Jin-Cong Zhuo
Molecules 1999, 4(11), M118; https://doi.org/10.3390/M118 - 23 Nov 1999
Cited by 3 | Viewed by 2743
Abstract
Method A: A mixture of methyl propiolate (0.42 g, 5 mmol) and aniline (0.47 g, 5 mmol) in MeCN (3 ml) was heated at 100ºC in a sealed-tube for 1 h.[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
83 KiB  
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1,3-Bis(pyrrolidin-2-on-1-yl)but-1-ene
by Jin-Cong Zhuo
Molecules 1999, 4(11), M117; https://doi.org/10.3390/M117 - 23 Nov 1999
Cited by 7 | Viewed by 2749
Abstract
To a solution of 1-vinyl-2-pyrrolidinone (1, 11.1 g, 100 mmol) in CH2Cl2 (100 ml) was added a drop of CF3CO2H at room temperature. Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
91 KiB  
Short Note
1-Hydroxymethyl-3-ethoxy-5-methylpyrazole
by Rachid Touzani, Abdelkrim Ramdani, Sghir El Kadiri and Fabienne Gourand
Molecules 1999, 4(11), M116; https://doi.org/10.3390/M116 - 23 Nov 1999
Cited by 13 | Viewed by 3568
Abstract
The product 2 was prepared by the addition of formalin (CH2O) to 1 [1] according to the reported procedure [2].[...] Full article
(This article belongs to the Section Molbank Section of Molecules, 1997-2001)
61 KiB  
Article
17O NMR Spectra of α,β-Unsaturated Carbonyl Compounds RCH=CHCOX: the Influence of Group X on the δ(17O) Value of the Carbonyl Oxygen and on the Shielding Effect of Group R
by Jin-Cong Zhuo
Molecules 1999, 4(11), 320-328; https://doi.org/10.3390/41100320 - 26 Oct 1999
Cited by 6 | Viewed by 12168
Abstract
17O NMR spectra of RCOX (R = Me, Ph), RCH=CHCOX (R = H, Ph, Me, CO2Et) and Me2C=CHCOX (X = H, Me, Et, i-Pr, t-Bu, Ph, PhCH=CH, OMe, OEt, Cl, CN, CF3, CO2Et) are [...] Read more.
17O NMR spectra of RCOX (R = Me, Ph), RCH=CHCOX (R = H, Ph, Me, CO2Et) and Me2C=CHCOX (X = H, Me, Et, i-Pr, t-Bu, Ph, PhCH=CH, OMe, OEt, Cl, CN, CF3, CO2Et) are reported. The 17O shift values of these carbonyl compounds depend mainly on the electron donating power of X and correlate well with the resonance constants sR+ of X. This suggests that the d(17O) values can be used to reflect qualitatively the electrophilicity of the carbonyl group. The shielding effect of the substituent R in RCH=CHCOX is diminished with increasing the electronic donating power of X and correlates with s+ values of X. Full article
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Scheme 1

22 KiB  
Article
8-Chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazino]-5H-dibenzo[b,e][1,4]diazepine
by Ben Capuano
Molecules 1999, 4(11), 329-332; https://doi.org/10.3390/41100329 - 25 Oct 1999
Cited by 4 | Viewed by 6051
Abstract
A method to synthesize desmethylclozapine, 3, is reported. The procedure afforded the target compound in 69% yield. A by-product, isolated from the reaction mixture in 11% yield, proved to be the title compound, 4. Full article
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Scheme 1

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