Molecules, Volume 4, Issue 11

N-Substituted amides and lactams are rapidly N-alkylated under solvent-free phase-transfer catalytic conditions using microwaves.

The product 2 was prepared by the addition of formalin (CH2O) to 1 [1] according to the reported procedure [2].[...]

To a solution of 1-vinyl-2-pyrrolidinone (1, 11.1 g, 100 mmol) in CH2Cl2 (100 ml) was added a drop of CF3CO2H at room temperature.

Method A: A mixture of methyl propiolate (0.42 g, 5 mmol) and aniline (0.47 g, 5 mmol) in MeCN (3 ml) was heated at 100ºC in a sealed-tube for 1 h.[...]

2-Cyanomethylthiopyridine (2) was prepared by the reaction of the pyridinethione 1 with chloroacetonitrile using literature procedures [1, 2].[...]

4-{[3-cyano-4-(methoxymethyl)-6-methyl-2-pyridinyl]oxy}benzoic acid 3 was prepared by the reaction of the 2-chloro-3-cyanopyridine 1 with 4-hydroxybenzoic acid 2 using a literature procedure [1].[...]

To a solution of 4-chlorobenzaldehyde oxime (0.40g) in CH2Cl2 (10 mL) in a large test-tube were added 1.0 mL of cyclododecene and 3 drops of triethylamine.[...]

To a solution of 4-chlorobenzaldehyde oxime ( 0.40g) in CH2Cl2 (10 mL) in a large test-tube were added 1.0 mL of cycloheptene and 3 drops of triethylamine.[...]

To a solution of 4-chlorobenzaldehyde oxime (0.40g ) in CH2Cl2 (10 mL) in a large test-tube were added 1.0 mL of cyclooctene and 3 drops of triethylamine.[...]

To a solution of 4-chlorobenzaldehyde oxime (0.40g) in CH2Cl2 (10 mL) in a large test-tube were added 1.0 mL of 1-dodecene and 3 drops of triethylamine.