Molecules, Volume 3, Issue 1

This review describes the history of the "Molecule of the Month" Website, along with a short summary of some of the molecules which featured during 1997.

Recent results from the author's laboratory in the area of dihydropyrimidine chemistry are summarized.

The preparation of a series of new 3-(alkynyl-X)-substituted 4-pyridazinecarbonitriles 2-5 (X = O, NH) is described. The compounds are shown to undergo thermally induced intramolecular Diels-Alder reactions with inverse electron demand, affording the...

The synthesis and biological evaluation of 14β-methoxy derivatives of digitoxigenin and of other digitalis-like compounds are reported. These compounds have a 14β-oxygen, which can be a hydrogen bonding acceptor, as is the case of 14β,15β-epoxide der...

The nucleophilic addition of 2-furyllithium to esters derived from L-serine is described. The obtained furyl ketone 5 is stereoselectively reduced (ds≥95%) with sodium borohydride to afford the corresponding syn aminoalcohol 12 in enantiomerically pu...

To a stirred suspension of dry sodium acetylacetonate (1.83g, 15mmol) in 20 ml CH3CN at 0deg.C freshly prepared bis(5-methylfur-2-yl)methylperchlorate [1] (2.74g, 10mmol) was added in small portions waiting for decolouration between each one.[...]

The mixture of 2-bromophenylbis(5-methylfur-2-yl)methane [1] (16.55 g, 50 mmol), 5 g CuCN and 5 ml of dry pyridine was heated for 12 hr on the oil bath at 220deg.C, then cooled to 150deg.C and poured onto a mixture of 10 ml ethylenediamine in 100 ml...

See also [1].[...]