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Molecules
Volume 26
Issue 18
10.3390/molecules26185659
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Article
Peer-Review Record

Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach

Molecules 2021, 26(18), 5659; https://doi.org/10.3390/molecules26185659
by Rebecca M. Rodriguez 1,2,3, Mark Menor 1, Brenda Y. Hernandez 2, Youping Deng 1,* and Vedbar S. Khadka 1,*
Reviewer 1: Anonymous
Molecules 2021, 26(18), 5659; https://doi.org/10.3390/molecules26185659
Submission received: 30 July 2021 / Revised: 15 September 2021 / Accepted: 15 September 2021 / Published: 17 September 2021
(This article belongs to the Special Issue Recent Progress on Biomarkers in the Diagnosis and Prognosis of Cancer)

Round 1

Reviewer 1 Report

The paper is interesting idea based on TCGA big database. I have some questions for the authors.

  1. Why use LIHC as abbreviation of hepatocellular carcinoma?
  2. The sample of Asian and black population to condclude the difference of bacterial diversity and racial groups, especially in HNSC and LIHC.
  3. In table 1, what is the meaning of "deceased" or "living" viral status?
  4. How to confirm the EBV status in TCGA data? In addition, the percentage of EBV positive and HPV positive in HNSC is equal. Was it a common distribution in literature review? How many patients with co-infected EBV and HPV?
  5. Because differnet bacterial diversity between normal tissue and tumor tissue is correalted with survival, the authors can try to explain that why male HNSC with high bacterial diversity in noramal tissue have poorer survival?
  6. In page 9, why authors commented "HPV status appeared to have an effect on ......and smoking status". Please clarify it clearly.
  7. The exposure of antibioitics within weeks before sample approach imapacts on bacterial diversity in tumor and normal tissue. Was available records of antibioitcs inTCGA, such as treatment fo H. Pylori infection?
  8. What is the percentage of HCV infection in LIHC?

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Very interesting paper where to be reviews the role of infectious agents against the appearance of certain cancers: liver, head and neck, gastric.

The authors evaluated various microbial sequences from a set of cancers associated with infectious agents.

In my opinion the methodology used is adequate to the objectives of the study as well as the analysis of the obtained data.The results well presented and the discussion and conclusions , correct.

The article can be published in the current version.

Author Response

We thank the Reviewer for carefully reading our manuscript and supporting our research work! 

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