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How Computational Chemistry and Drug Delivery Techniques Can Support the Development of New Anticancer Drugs

1
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy
2
Department of Pharmaceutical Sciences, University of Milano, 20133 Milan, Italy
3
Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
4
Institute for Research in Biomedicine (IRB), Università della Svizzera Italiana (USI), 6500 Bellinzona, Switzerland
*
Authors to whom correspondence should be addressed.
Molecules 2020, 25(7), 1756; https://doi.org/10.3390/molecules25071756
Received: 13 March 2020 / Revised: 6 April 2020 / Accepted: 8 April 2020 / Published: 10 April 2020
(This article belongs to the Special Issue Peptides and Small Molecules as Anti-Cancer Agents)
The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) techniques, although apparently far from each other, are two research fields that can give a significant contribution to overcome these problems. Their combination may provide mechanistic understanding resulting in a synergy that makes possible the rational design of novel anticancer based therapies. Herein, we aim to discuss selected applications, some also from our research experience, in the fields of anticancer small organic drugs and peptides. View Full-Text
Keywords: drug delivery; computational chemistry; anticancer drug design drug delivery; computational chemistry; anticancer drug design
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MDPI and ACS Style

Garofalo, M.; Grazioso, G.; Cavalli, A.; Sgrignani, J. How Computational Chemistry and Drug Delivery Techniques Can Support the Development of New Anticancer Drugs. Molecules 2020, 25, 1756. https://doi.org/10.3390/molecules25071756

AMA Style

Garofalo M, Grazioso G, Cavalli A, Sgrignani J. How Computational Chemistry and Drug Delivery Techniques Can Support the Development of New Anticancer Drugs. Molecules. 2020; 25(7):1756. https://doi.org/10.3390/molecules25071756

Chicago/Turabian Style

Garofalo, Mariangela, Giovanni Grazioso, Andrea Cavalli, and Jacopo Sgrignani. 2020. "How Computational Chemistry and Drug Delivery Techniques Can Support the Development of New Anticancer Drugs" Molecules 25, no. 7: 1756. https://doi.org/10.3390/molecules25071756

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