Review Reports - Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections

Round 1

Reviewer 1 Report

This manuscript, aims to review recent advances in polymeric nanoparticle-encapsulated drugs against intracellular Infections. This is an area of interest for me and has not being well reviewed in the literature. The manuscript is well written, most of the review focuses on describing conventional nanoparticle technologies, methods of fabrication, mechanism of drug release and strategies for targeted delivery of drugs. This information can be found in a mountain of Review manuscripts on nanomedicines. I believe this manuscript would be of greater value if the Review focused more on describing where pathogens reside/hide in the body, including to the level of intracellular compartments, how nanomedicines have been or could be designed to target the locations, which diseases would be best targeted using nanomedicines? While it is an interesting subject, this manuscript in its current form is not suitable as it is not focused on intracellular infections.

Author Response

Dear Reviewer 1,

Thank you for your response and the enclosed comments regarding our review "Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs Against Intracellular Infections", molecules-870820. We found these comments to be very favorable; the suggestions very useful and revised the manuscript for addressing all the comments. Please find a corrected version of the manuscript and specific/itemized details of all our changes clearly highlighted (in track editing) in the enclosed 'Corrected copy' and the list of changes (below).

Sincerely,

Jahir Orozco Holguín, PhD,

Group Leader Max

Planck Tandem Group in Nanobioengineering

Universidad de Antioquia

Complejo Ruta N, Torre A, Laboratorio 4-166

Calle 67, Nº 52-20, Medellín, 050010, Colombia

e-mail: grupotandem.nanobioe@udea.edu.co

Tel : (+57) 313 444 8129

Author Response File: Author Response.docx

Reviewer 2 Report

A survey on polymer-based drug deliver systems (DDS) targeted to intracellular infections is proposed. DDS as a whole is a very current and quite relevant topic whose interdisciplinary nature offers a wide range of subtopic-oriented review articles. Bearing this in mind, the manuscript is publishable if substantially shortened. Indeed, while being evident that the subject is well devised and that the manuscript was carefully prepared with a clear writing, there is a superfluous dispersion with some (well-known and widely reported) content that either does not actually represent a clear advance related to the title formulations, or does not correspond to the focus of the topic under review. There are several examples supporting this point of view, viz. lines 472-527 (on mathematical models for drug release) and most of the content of section 3 (which sounds as a nice pedagogical piece of work for a cellular microbiology textbook or so). Even the content of section 5 is not exclusive of systems based on polymeric nanoparticle-encapsulated drugs; it generally applies also to other antimicrobial nanomaterials, namely metal-based nano-conjugates targeted also to intracellular infections therapy. According to these observations, the authors are challenged to propose a shortened version of their work that includes the essentials of ``Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs Against Intracellular Infections''.