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Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application
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Anything You Can Do, I Can Do Better: Can Aptamers Replace Antibodies in Clinical Diagnostic Applications?

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School of Medicine Deakin University, Geelong, Victoria 3128, Australia
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Centre for Molecular and Medical Research, Deakin University, Geelong, Victoria 3128, Australia
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Author to whom correspondence should be addressed.
Academic Editor: Laura Cerchia
Molecules 2019, 24(23), 4377; https://doi.org/10.3390/molecules24234377
Received: 7 November 2019 / Revised: 28 November 2019 / Accepted: 28 November 2019 / Published: 30 November 2019
(This article belongs to the Special Issue Aptamers: Successes, Limitations and Future Directions)
The mainstay of clinical diagnostics is the use of specialised ligands that can recognise specific biomarkers relating to pathological changes. While protein antibodies have been utilised in these assays for the last 40 years, they have proven to be unreliable due to a number of reasons. The search for the ‘perfect’ targeting ligand or molecular probe has been slow, though the description of chemical antibodies, also known as aptamers, nearly 30 years ago suggested a replacement reagent. However, uptake has been slow to progress into the clinical environment. In this review, we discuss the issues associated with antibodies and describe some of the applications of aptamers that have relevancy to the clinical diagnostic environment. View Full-Text
Keywords: aptamers; antibodies; clinical; diagnostics; immunohistochemistry; immunophenotyping; lateral flow devices aptamers; antibodies; clinical; diagnostics; immunohistochemistry; immunophenotyping; lateral flow devices
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Bauer, M.; Strom, M.; Hammond, D.S.; Shigdar, S. Anything You Can Do, I Can Do Better: Can Aptamers Replace Antibodies in Clinical Diagnostic Applications? Molecules 2019, 24, 4377.

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