Next Article in Journal
Neuroprotective Norsesquiterpenoids and Triterpenoids from Populus euphratica Resins
Previous Article in Journal
Anything You Can Do, I Can Do Better: Can Aptamers Replace Antibodies in Clinical Diagnostic Applications?
Open AccessArticle

Green Synthesis and Electrochemical Properties of Mono- and Dimers Derived from Phenylaminoisoquinolinequinones

1
Facultad de Química y Biología, Universidad de Santiago de Chile, Alameda 3363, casilla 40, Santiago 9170022, Chile
2
Facultad de Ciencias de la Salud, Universidad Arturo Prat, casilla 121, Iquique 1100000, Chile
3
Facultad de Química y Farmacia, Universidad Católica de Chile, casilla 306, Santiago 7820436, Chile
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(23), 4378; https://doi.org/10.3390/molecules24234378
Received: 28 October 2019 / Revised: 25 November 2019 / Accepted: 26 November 2019 / Published: 30 November 2019
(This article belongs to the Section Organic Chemistry)
In the search for new quinoid compounds endowed with potential anticancer activity, the synthesis of novel heterodimers containing the cytotoxic 7-phenylaminoisoquinolinequinone and 2-phenylaminonaphthoquinone pharmacophores, connected through methylene and ethylene spacers, is reported. The heterodimers were prepared from their respective isoquinoline and naphthoquinones and 4,4′-diaminodiphenyl alkenes. The access to the target heterodimers and their corresponding monomers was performed both through oxidative amination reactions assisted by ultrasound and CeCl3·7H2O catalysis “in water”. This eco-friendly procedure was successfully extended to the one-pot synthesis of homodimers derived from the 7-phenylaminoisoquinolinequinone pharmacophore. The electrochemical properties of the monomers and dimers were determined by cyclic and square wave voltammetry. The number of electrons transferred during the oxidation process, associated to the redox potential EI1/2, was determined by controlled potential coulometry. View Full-Text
Keywords: twin drugs; heterodimers; green synthesis; amination reaction; cyclic voltammetry; half-wave potential twin drugs; heterodimers; green synthesis; amination reaction; cyclic voltammetry; half-wave potential
Show Figures

Figure 1

MDPI and ACS Style

Ibacache, J.A.; Valderrama, J.A.; Faúndes, J.; Danimann, A.; Recio, F.J.; Zúñiga, C.A. Green Synthesis and Electrochemical Properties of Mono- and Dimers Derived from Phenylaminoisoquinolinequinones. Molecules 2019, 24, 4378.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop