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Article

Potential Photoprotective Effect of Dietary Corn Silk Extract on Ultraviolet B-Induced Skin Damage

by
Yeon-hee Kim
1,†,
Amy Cho
1,†,
Sang-Ah Kwon
1,
Minju Kim
1,
Mina Song
1,
Hye won Han
1,
Eun-Ji Shin
2,
Eunju Park
2 and
Seung-Min Lee
1,*
1
Department of Food and Nutrition, BK21 PLUS Project, College of Human Ecology, Yonsei University, Seoul 03722, Korea
2
Department of Food and Nutritional Science, Kyungnam University, Changwon 51767, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2019, 24(14), 2587; https://doi.org/10.3390/molecules24142587
Submission received: 27 May 2019 / Revised: 11 July 2019 / Accepted: 15 July 2019 / Published: 16 July 2019
(This article belongs to the Special Issue Plant Extracts: Biological and Pharmacological Activity)
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Abstract

Ultraviolet B (UVB) irradiation causes adverse effects on the skin. Corn silk contains flavonoids and other bioactive compounds and antioxidants, which may prevent skin photoaging through antioxidant and anti-inflammatory effects. We aimed to investigate the potential photoprotective effects of dietary corn silk on UVB-induced skin damage in mice and the mechanisms behind these effects on human skin cells. Oral administration of corn silk water extract (CS) (2 or 4 g/kg/day) for 19 weeks decreased epidermal thickness, wrinkle formation, and positive staining for PCNA, Ki67, and 8-OHdG, and increased collagen staining in UVB-irradiated SKH-1 hairless mice compared with controls. The pro-inflammatory NF-κB target genes (IL-1β, iNOS, and COX-2) and MMP-9 expressions were lower in the CS groups, and TGF-β/Smad signaling increased. Low skin lipid peroxidation and blood DNA oxidation levels and high blood glutathione were detected. Antioxidant transcription factor Nrf2-related catalase and SOD1 proteins and glutaredoxin mRNA levels increased. The results of CS extract treatment and UVB irradiation in HaCaT cells showed the same results in Nrf2 and NF-κB target genes. An LC-MS/MS analysis showed that the CS extract contained potential antioxidants, which might have contributed to its anti-photoaging effects in tissues and cells. CS extract may reduce UVB-induced skin damage through antioxidant and anti-inflammatory mechanisms.
Keywords: corn silk extract; photoaging; ultraviolet B; NF-κB; antioxidant; inflammation corn silk extract; photoaging; ultraviolet B; NF-κB; antioxidant; inflammation
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MDPI and ACS Style

Kim, Y.-h.; Cho, A.; Kwon, S.-A.; Kim, M.; Song, M.; Han, H.w.; Shin, E.-J.; Park, E.; Lee, S.-M. Potential Photoprotective Effect of Dietary Corn Silk Extract on Ultraviolet B-Induced Skin Damage. Molecules 2019, 24, 2587. https://doi.org/10.3390/molecules24142587

AMA Style

Kim Y-h, Cho A, Kwon S-A, Kim M, Song M, Han Hw, Shin E-J, Park E, Lee S-M. Potential Photoprotective Effect of Dietary Corn Silk Extract on Ultraviolet B-Induced Skin Damage. Molecules. 2019; 24(14):2587. https://doi.org/10.3390/molecules24142587

Chicago/Turabian Style

Kim, Yeon-hee, Amy Cho, Sang-Ah Kwon, Minju Kim, Mina Song, Hye won Han, Eun-Ji Shin, Eunju Park, and Seung-Min Lee. 2019. "Potential Photoprotective Effect of Dietary Corn Silk Extract on Ultraviolet B-Induced Skin Damage" Molecules 24, no. 14: 2587. https://doi.org/10.3390/molecules24142587

APA Style

Kim, Y.-h., Cho, A., Kwon, S.-A., Kim, M., Song, M., Han, H. w., Shin, E.-J., Park, E., & Lee, S.-M. (2019). Potential Photoprotective Effect of Dietary Corn Silk Extract on Ultraviolet B-Induced Skin Damage. Molecules, 24(14), 2587. https://doi.org/10.3390/molecules24142587

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