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Mussel-Inspired Catechol-Functionalized Hydrogels and Their Medical Applications

1
Department of Applied Chemistry, School of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China
2
Key Laboratory of Tropical Crop Products Processing of Ministry of Agriculture and Rural Affairs, Agricultural Product Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang 524001, China
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(14), 2586; https://doi.org/10.3390/molecules24142586
Received: 11 May 2019 / Revised: 13 July 2019 / Accepted: 13 July 2019 / Published: 16 July 2019
Mussel adhesive proteins (MAPs) have a unique ability to firmly adhere to different surfaces in aqueous environments via the special amino acid, 3,4-dihydroxyphenylalanine (DOPA). The catechol groups in DOPA are a key group for adhesive proteins, which is highly informative for the biomedical domain. By simulating MAPs, medical products can be developed for tissue adhesion, drug delivery, and wound healing. Hydrogel is a common formulation that is highly adaptable to numerous medical applications. Based on a discussion of the adhesion mechanism of MAPs, this paper reviews the formation and adhesion mechanism of catechol-functionalized hydrogels, types of hydrogels and main factors affecting adhesion, and medical applications of hydrogels, and future the development of catechol-functionalized hydrogels. View Full-Text
Keywords: mussel adhesive protein; catechol; hydrogel; medical application mussel adhesive protein; catechol; hydrogel; medical application
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MDPI and ACS Style

Quan, W.-Y.; Hu, Z.; Liu, H.-Z.; Ouyang, Q.-Q.; Zhang, D.-Y.; Li, S.-D.; Li, P.-W.; Yang, Z.-M. Mussel-Inspired Catechol-Functionalized Hydrogels and Their Medical Applications. Molecules 2019, 24, 2586. https://doi.org/10.3390/molecules24142586

AMA Style

Quan W-Y, Hu Z, Liu H-Z, Ouyang Q-Q, Zhang D-Y, Li S-D, Li P-W, Yang Z-M. Mussel-Inspired Catechol-Functionalized Hydrogels and Their Medical Applications. Molecules. 2019; 24(14):2586. https://doi.org/10.3390/molecules24142586

Chicago/Turabian Style

Quan, Wei-Yan; Hu, Zhang; Liu, Hua-Zhong; Ouyang, Qian-Qian; Zhang, Dong-Ying; Li, Si-Dong; Li, Pu-Wang; Yang, Zi-Ming. 2019. "Mussel-Inspired Catechol-Functionalized Hydrogels and Their Medical Applications" Molecules 24, no. 14: 2586. https://doi.org/10.3390/molecules24142586

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