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Molecules 2019, 24(1), 213; https://doi.org/10.3390/molecules24010213

Monitoring Antifungal Agents of Artemisia annua against Fusarium oxysporum and Fusarium solani, Associated with Panax notoginseng Root-Rot Disease

1
College of Pharmaceutical Sciences, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China
2
School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China
*
Authors to whom correspondence should be addressed.
Received: 14 December 2018 / Revised: 2 January 2019 / Accepted: 3 January 2019 / Published: 8 January 2019
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Abstract

Root rot of Panax notoginseng has received great attention due to its threat on the plantation and sustainable utilization of P. notoginseng. To suppress the root-rot disease, natural ingredients are of great importance because of their environment friendly properties. In this study, we found that the methanol extract from Artemisia annua leaves has strong antifungal effects on the growth of Fusarium oxysporum and Fusarium solani resulting into root-rot disease. Essential oil (EO) thereof was found to be the most active. GC-MS analysis revealed 58 ingredients and camphor, camphene, β-caryophyllene, and germacrene D were identified as the major ingredients. Further antifungal assays showed that the main compounds exhibit various degrees of inhibition against all the fungi tested. In addition, synergistic effects between A. annua EO and chemical fungicides were examined. Finally, in vivo experiments were conducted and disclosed that P. notoginseng root rot could be largely inhibited by the petroleum ether extract from A. annua, indicating that A. annua could be a good source for controlling P. notoginseng root-rot. View Full-Text
Keywords: Artemisia annua; essential oil; Panax notoginseng; root rot; Fusarium oxysporum; Fusarium solani Artemisia annua; essential oil; Panax notoginseng; root rot; Fusarium oxysporum; Fusarium solani
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Ma, Y.-N.; Chen, C.-J.; Li, Q.-Q.; Xu, F.-R.; Cheng, Y.-X.; Dong, X. Monitoring Antifungal Agents of Artemisia annua against Fusarium oxysporum and Fusarium solani, Associated with Panax notoginseng Root-Rot Disease. Molecules 2019, 24, 213.

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