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Molecules 2018, 23(5), 1185; https://doi.org/10.3390/molecules23051185

Study on the Polar Extracts of Dendrobium nobile, D. officinale, D. loddigesii, and Flickingeria fimbriata: Metabolite Identification, Content Evaluation, and Bioactivity Assay

1
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
2
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
*
Authors to whom correspondence should be addressed.
Received: 16 March 2018 / Revised: 10 May 2018 / Accepted: 10 May 2018 / Published: 15 May 2018
(This article belongs to the Collection Bioactive Compounds)
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Abstract

The polar extract of the Dendrobium species or F. fimbriata (a substitute of Dendrobium), between the fat-soluble extract and polysaccharide has barely been researched. This report worked on the qualitative and quantitative studies of polar extracts from D. nobile, D. officinale, D. loddigesii, and F. fimbriata. Eight water-soluble metabolites containing a new diglucoside, flifimdioside A (1), and a rare imidazolium-type alkaloid, anosmine (4), were identified using chromatography as well as spectroscopic techniques. Their contents in the four herbs were high, approximately 0.9–3.7 mg/g based on the analysis of quantitative nuclear magnetic resonance (qNMR) spectroscopy. Biological activity evaluation showed that the polar extract of F. fimbriata or its pure component had good antioxidant and neuroprotective activity; compounds 14 and shihunine (8) showed weak α-glucosidase inhibitory activity; 4 and 8 had weak anti-inflammatory activity. Under trial conditions, all samples had no cytotoxic activity. View Full-Text
Keywords: Dendrobium; Flickingeria fimbriata; qNMR; α-glucosidase inhibition; antioxygenation; neuroprotection Dendrobium; Flickingeria fimbriata; qNMR; α-glucosidase inhibition; antioxygenation; neuroprotection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, H.; Li, X.; Xu, Y.; Lo, K.; Zheng, H.; Hu, H.; Wang, J.; Lin, Y. Study on the Polar Extracts of Dendrobium nobile, D. officinale, D. loddigesii, and Flickingeria fimbriata: Metabolite Identification, Content Evaluation, and Bioactivity Assay. Molecules 2018, 23, 1185.

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