Next Article in Journal
Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents
Next Article in Special Issue
Molecularly Imprinted Polymers as Extracting Media for the Chromatographic Determination of Antibiotics in Milk
Previous Article in Journal
Structure, Chemical Analysis, Biosynthesis, Metabolism, Molecular Engineering, and Biological Functions of Phytoalexins
Previous Article in Special Issue
Fast Extraction and Detection of 4-Methylimidazole in Soy Sauce Using Magnetic Molecularly Imprinted Polymer by HPLC
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessCommunication
Molecules 2018, 23(1), 63; https://doi.org/10.3390/molecules23010063

Molecularly Imprinted Microrods via Mesophase Polymerization

1
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende (CS), Italy
2
Macrofarm s.r.l., c/o Department of Pharmacy, Health and Nutrition Sciences, University of Calabria, 87036 Rende (CS), Italy
3
Department of Environmental and Chemical Engineering, University of Calabria, 87036 Rende (CS), Italy
4
Faculty of Pharmacy, CAMB, UMR 7199, CNRS-University of Strasbourg, 67400 Illkirch, France
*
Author to whom correspondence should be addressed.
Received: 2 November 2017 / Revised: 21 December 2017 / Accepted: 22 December 2017 / Published: 28 December 2017
(This article belongs to the Special Issue Synthesis and Applications of Molecularly Imprinted Polymers)
Full-Text   |   PDF [536 KB, uploaded 28 December 2017]   |  

Abstract

The aim of the present research work was the synthesis of molecularly imprinted polymers (MIPs) with a rod-like geometry via “mesophase polymerization”. The ternary lyotropic system consisting of sodium dodecyl sulfate (SDS), water, and decanol was chosen to prepare a hexagonal mesophase to direct the morphology of the synthesized imprinted polymers using theophylline, methacrylic acid, and ethylene glycol dimethacrylate as a drug model template, a functional monomer, and a crosslinker, respectively. The obtained molecularly imprinted microrods (MIMs) were assessed by performing binding experiments and in vitro release studies, and the obtained results highlighted good selective recognition abilities and sustained release properties. In conclusion, the adopted synthetic strategy involving a lyotropic mesophase system allows for the preparation of effective MIPs characterized by a rod-like morphology. View Full-Text
Keywords: molecularly imprinted polymers; polymeric microrods; mesophase polymerization; theophylline molecularly imprinted polymers; polymeric microrods; mesophase polymerization; theophylline
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Parisi, O.I.; Scrivano, L.; Candamano, S.; Ruffo, M.; Vattimo, A.F.; Spanedda, M.V.; Puoci, F. Molecularly Imprinted Microrods via Mesophase Polymerization. Molecules 2018, 23, 63.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top