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Molecules 2017, 22(5), 714;

Markers of Oxidative Stress and Antioxidant Defense in Romanian Patients with Type 2 Diabetes Mellitus and Obesity

NIDNMD “Prof. N.C. Paulescu”, 2th district, Bucharest 020042, Romania
Faculty of Biology, University of Bucharest, 5th district, Bucharest 050095, Romania
Department of Biochemstry, University of Medicine and Pharmacy “Carol Davila”, 5th district, Bucharest 050474, Romania
Research Institute of the University of Bucharest, ICUB, 5th district, Bucharest 050107, Romania
Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rareș Str., Craiova 200638, Romania
Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Received: 13 March 2017 / Revised: 14 April 2017 / Accepted: 26 April 2017 / Published: 1 May 2017
(This article belongs to the Special Issue Chemistry and Pharmacology of Modulators of Oxidative Stress)
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Type 2 diabetes mellitus (T2DM) is strongly associated with obesity. The adipose tissue secretes bioactive adipokines leading to low grade inflammation, amplified by oxidative stress, which promotes the formation of advanced glycation end products and eventually leads to dyslipidemia and vascular complications. The aim of this study was to correlate anthropometric, biochemical and oxidative stress parameters in newly diagnosed (ND) T2DM patients and to investigate the role of oxidative stress in T2DM associated with obesity. A group of 115 ND- T2DM patients was compared to a group of 32 healthy subjects in terms of clinical, anthropometric, biochemical and oxidative stress parameters. ND-T2DM patients had significantly lower adiponectin, glutathione (GSH) and gluthatione peroxidase (GPx) and elevated insulin, proinsulin, HOMA-IR index, proinsulin/insulin (P/I) and proinsulin/adiponectin (P/A) ratio, fructosamine, and total oxidant status (TOS). The total body fat mass was positively correlated with total oxidant status (TOS). Positive correlations were found between TOS and glycated hemoglobin (HbA1c), and between TOS and glycaemia. Negative correlations were identified between: GPx and glycaemia, GPx and HbA1c, and also between GSH and fructosamine. The total antioxidant status was negatively correlated with the respiratory burst. The identified correlations suggest the existence of a complex interplay between diabetes, obesity and oxidative stress. View Full-Text
Keywords: oxidative stress; type 2 diabetes mellitus; obesity; reactive oxygen species; inflammation oxidative stress; type 2 diabetes mellitus; obesity; reactive oxygen species; inflammation

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Picu, A.; Petcu, L.; Ştefan, S.; Mitu, M.; Lixandru, D.; Ionescu-Tîrgovişte, C.; Pîrcălăbioru, G.G.; Ciulu-Costinescu, F.; Bubulica, M.-V.; Chifiriuc, M.C. Markers of Oxidative Stress and Antioxidant Defense in Romanian Patients with Type 2 Diabetes Mellitus and Obesity. Molecules 2017, 22, 714.

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