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Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review

Faculty of Pharmacy, Shaanxi University of Science & Technology, 6 Xuefu Road, Xi’an 710021, China
Xi’an Taikomed Pharmaceutical technology Co., LTD, Xi’an 710077, China
Faculty of Finance and Economics, Guangzhou Vocational College of Science and Technology, Guangzhou 510550, China
Author to whom correspondence should be addressed.
Academic Editors: Dong-Kug Choi and Palanivel Ganesan
Molecules 2017, 22(3), 387;
Received: 7 February 2017 / Revised: 20 February 2017 / Accepted: 24 February 2017 / Published: 2 March 2017
(This article belongs to the Special Issue Natural Products and Chronic Diseases)
PDF [2934 KB, uploaded 2 March 2017]


Esculetin, synonymous with 6,7-dihydroxycoumarin, is the main active ingredient of the traditional Chinese medicine Cortex Fraxini. The twig skin or trunk bark of Cortex Fraxini are used by herb doctors as a mild, bitter liver and gallbladder meridians’ nontoxic drug as well as dietary supplement. Recently, with a variety of novel esculetin derivatives being reported, the molecular mechanism research as well as clinical application of Cortex Fraxini and esculetin are becoming more attractive. This mini-review will consolidate what is known about the biological activities, the mechanism of esculetin and its synthetic derivatives over the past decade in addition to providing a brief synopsis of the properties of esculetin. View Full-Text
Keywords: esculetin; coumarin; synthetic derivatives; pharmacological activity; molecular mechanism esculetin; coumarin; synthetic derivatives; pharmacological activity; molecular mechanism

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Liang, C.; Ju, W.; Pei, S.; Tang, Y.; Xiao, Y. Pharmacological Activities and Synthesis of Esculetin and Its Derivatives: A Mini-Review. Molecules 2017, 22, 387.

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