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The Diverse Range of Possible Cell Membrane Interactions with Substrates: Drug Delivery, Interfaces and Mobility

Center for Soft and Living Matter, Institute for Basic Science (IBS), Ulsan 44919, Korea
Molecules 2017, 22(12), 2197; https://doi.org/10.3390/molecules22122197
Received: 30 October 2017 / Revised: 30 November 2017 / Accepted: 7 December 2017 / Published: 11 December 2017
(This article belongs to the Special Issue Phospholipids: Structure and Function)
The cell membrane has gained significant attention as a platform for the development of bio-inspired nanodevices due to its immune-evasive functionalities and copious bio-analogs. This review will examine several uses of cell membranes such as (i) therapeutic delivery carriers with or without substrates (i.e., nanoparticles and artificial polymers) that have enhanced efficiency regarding copious cargo loading and controlled release, (ii) exploiting nano-bio interfaces in membrane-coated particles from the macro- to the nanoscales, which would help resolve the biomedical issues involved in biological interfacing in the body, and (iii) its effects on the mobility of bio-moieties such as lipids and/or proteins in cell membranes, as discussed from a biophysical perspective. We anticipate that this review will influence both the development of novel anti-phagocytic delivery cargo and address biophysical problems in soft and complex cell membrane. View Full-Text
Keywords: bio-membrane; nanocarriers; bio-interfaces; mobility; nanoparticles bio-membrane; nanocarriers; bio-interfaces; mobility; nanoparticles
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Jang, H.-S. The Diverse Range of Possible Cell Membrane Interactions with Substrates: Drug Delivery, Interfaces and Mobility. Molecules 2017, 22, 2197.

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