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Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine

Istituto Farmaceutico Candioli, Beinasco (To) 10092, Italy
Department of Veterinary Sciences, University of Torino, Torino 10095, Italy
Department of Life Sciences and Systems Biology, University of Torino, Torino 10123, Italy
Ambulatorio Veterinario Associato, Torino 10135, Italy
Department of Drug Science and Technology, University of Torino, Torino 10125, Italy
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2016, 21(6), 752;
Received: 18 May 2016 / Revised: 3 June 2016 / Accepted: 6 June 2016 / Published: 11 June 2016
PDF [1188 KB, uploaded 11 June 2016]


Antimicrobial peptides (AMPs) represent a vast array of molecules produced by virtually all living organisms as natural barriers against infection. Among AMP sources, an interesting class regards the food-derived bioactive agents. The whey protein lactoferrin (Lf) is an iron-binding glycoprotein that plays a significant role in the innate immune system, and is considered as an important host defense molecule. In search for novel antimicrobial agents, Lf offers a new source with potential pharmaceutical applications. The Lf-derived peptides Lf(1–11), lactoferricin (Lfcin) and lactoferrampin exhibit interesting and more potent antimicrobial actions than intact protein. Particularly, Lfcin has demonstrated strong antibacterial, anti-fungal and antiparasitic activity with promising applications both in human and veterinary diseases (from ocular infections to osteo-articular, gastrointestinal and dermatological diseases). View Full-Text
Keywords: antimicrobial peptides; lactoferricin; milk proteins; food safety antimicrobial peptides; lactoferricin; milk proteins; food safety

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Bruni, N.; Capucchio, M.T.; Biasibetti, E.; Pessione, E.; Cirrincione, S.; Giraudo, L.; Corona, A.; Dosio, F. Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine. Molecules 2016, 21, 752.

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