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Cinidium officinale and its Bioactive Compound, Butylidenephthalide, Inhibit Laser-Induced Choroidal Neovascularization in a Rat Model

by Yun Mi Lee 1,2, Yu Ri Lee 2, Jin Sook Kim 2, Young Ho Kim 1,† and Junghyun Kim 2,*,†
1
College of Pharmacy, Chungnam National University, Daejeon 34134, Korea
2
Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea
*
Author to whom correspondence should be addressed.
These authors are co-corresponding authors.
Academic Editor: Derek J. McPhee
Molecules 2015, 20(11), 20699-20708; https://doi.org/10.3390/molecules201119728
Received: 1 October 2015 / Revised: 13 November 2015 / Accepted: 16 November 2015 / Published: 19 November 2015
(This article belongs to the Section Natural Products Chemistry)
Choroidal neovascularization (CNV) is a common pathology in age-related macular degeneration. In this study, we evaluated in a rat model the effect of an extract of Cinidium officinale Makino and its bioactive compound, butylidenephthalide, on laser-induced CNV. Experimental CNV was induced in Long-Evans rats by laser photocoagulation. C. officinale extract (COE) and butylidenephthalide was intraperitoneally injected once per day for ten days after laser photocoagulation. Choroidal flat mounts were prepared to measure CNV areas and macrophage infiltration. We used a protein array to evaluate the expression levels of angiogenic factors. The CNV area and macrophage infiltration in COE-treated rats were significantly lower than in vehicle-treated rats. COE decreased the expression levels of IGFBP-1, MCP-1, PAI-1, and VEGF. Additionally, butylidenephthalide also inhibited the laser-induced CNV formation and macrophage infiltration and down-regulated the expression of IGFBP-1, MCP-1 and VEGF. These results suggest that COE exerts anti-angiogenic effects on laser-induced CNV by inhibiting the expression of IGFBP-1, MCP-1, and VEGF, indicating that anti-angiogenic activities of COE may be in part due to its bioactive compound, butylidenephthalide. View Full-Text
Keywords: age-related macular degeneration; butylidenephthalide; choroidal neovascularization; Cinidium officinale age-related macular degeneration; butylidenephthalide; choroidal neovascularization; Cinidium officinale
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Lee, Y.M.; Lee, Y.R.; Kim, J.S.; Kim, Y.H.; Kim, J. Cinidium officinale and its Bioactive Compound, Butylidenephthalide, Inhibit Laser-Induced Choroidal Neovascularization in a Rat Model. Molecules 2015, 20, 20699-20708.

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