Next Article in Journal
Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment
Previous Article in Journal
Anticancer and Antibacterial Activity Studies of Gold(I)-Alkynyl Chromones
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(11), 19719-19734; https://doi.org/10.3390/molecules201119652

Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities

1
National Institute of Biological Resources, Environmental Research Complex, Incheon 404-708, Korea
2
Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 28 August 2015 / Revised: 22 October 2015 / Accepted: 23 October 2015 / Published: 2 November 2015
(This article belongs to the Section Natural Products Chemistry)
Full-Text   |   PDF [2290 KB, uploaded 2 November 2015]   |  

Abstract

Chemotaxonomic metabolite profiling of 62 indigenous Korean plant species was performed by ultrahigh performance liquid chromatography (UHPLC)-linear trap quadrupole-ion trap (LTQ-IT) mass spectrometry/mass spectrometry (MS/MS) combined with multivariate statistical analysis. In partial least squares discriminant analysis (PLS-DA), the 62 species clustered depending on their phylogenetic family, in particular, Aceraceae, Betulaceae, and Fagaceae were distinguished from Rosaceae, Fabaceae, and Asteraceae. Quinic acid, gallic acid, quercetin, quercetin derivatives, kaempferol, and kaempferol derivatives were identified as family-specific metabolites, and were found in relatively high concentrations in Aceraceae, Betulaceae, and Fagaceae. Fagaceae and Asteraceae were selected based on results of PLS-DA and bioactivities to determine the correlation between metabolic differences among plant families and bioactivities. Quinic acid, quercetin, kaempferol, quercetin derivatives, and kaempferol derivatives were found in higher concentrations in Fagaceae than in Asteraceae, and were positively correlated with antioxidant and tyrosinase inhibition activities. These results suggest that metabolite profiling was a useful tool for finding the different metabolic states of each plant family and understanding the correlation between metabolites and bioactivities in accordance with plant family. View Full-Text
Keywords: chemotaxonomy; indigenous plant; metabolite profiling; UHPLC-LTQ-IT-MS/MS; antioxidant activity; tyrosinase inhibition activity chemotaxonomy; indigenous plant; metabolite profiling; UHPLC-LTQ-IT-MS/MS; antioxidant activity; tyrosinase inhibition activity
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Lee, S.; Oh, D.-G.; Lee, S.; Kim, G.R.; Lee, J.S.; Son, Y.K.; Bae, C.-H.; Yeo, J.; Lee, C.H. Chemotaxonomic Metabolite Profiling of 62 Indigenous Plant Species and Its Correlation with Bioactivities. Molecules 2015, 20, 19719-19734.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top