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Open AccessArticle

Effect of Non-Pharmacologic Vitamin D Status Correction on Circulating Bone Markers in Healthy Overweight and Obese Saudis

1
Biomarkers Research Program, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
2
Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, King Saud University, Riyadh 11451, Saudi Arabia
3
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
4
College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia
5
College of Medicine, King Saud University for Health Sciences, Riyadh 14611, Saudi Arabia
6
Medicine Department, King Khalid University Hospital, Riyadh 12371, Saudi Arabia
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(9), 10671-10680; https://doi.org/10.3390/molecules180910671
Received: 1 June 2013 / Revised: 22 August 2013 / Accepted: 28 August 2013 / Published: 2 September 2013
While moderate to severe vitamin D deficiency is prevalent in Saudi Arabia, skeletal effects associated with this deficiency are not common in this population. In this interventional study we measured the effects of improving vitamin D status on bone biochemical markers in overweight and obese adult Saudis. A total of 47 volunteers (21 males, 26 females) out of the initial 95 subjects were given verbal advice to expose themselves to sunlight for 5–30 min twice weekly and were encouraged to increase their intake of vitamin D–rich foods. Serum 25(OH)D, osteocalcin, and type 1 collagen cross-linked C-telopeptide (CTx), were measured at baseline and after one year. A significant decrease in the prevalence of vitamin D deficiency was observed (44% to 27%) after one year follow-up (p = 0.025). Also, a parallel significant increase in osteocalcin and a decrease in CTX and osteoprotegerin were observed. The results suggest that a modest increase in vitamin D levels among overweight and obese subjects through the promotion of lifestyle changes for one year have marginal effects in bone turnover markers as well as obesity itself. View Full-Text
Keywords: vitamin D; bone formation marker; osteocalcin; bone resorption marker; CTX; healthy adults vitamin D; bone formation marker; osteocalcin; bone resorption marker; CTX; healthy adults
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MDPI and ACS Style

Al-Daghri, N.M.; Alkharfy, K.M.; Al-Othman, A.; Yakout, S.M.; Al-Saleh, Y.; Fouda, M.; Sabico, S. Effect of Non-Pharmacologic Vitamin D Status Correction on Circulating Bone Markers in Healthy Overweight and Obese Saudis. Molecules 2013, 18, 10671-10680. https://doi.org/10.3390/molecules180910671

AMA Style

Al-Daghri NM, Alkharfy KM, Al-Othman A, Yakout SM, Al-Saleh Y, Fouda M, Sabico S. Effect of Non-Pharmacologic Vitamin D Status Correction on Circulating Bone Markers in Healthy Overweight and Obese Saudis. Molecules. 2013; 18(9):10671-10680. https://doi.org/10.3390/molecules180910671

Chicago/Turabian Style

Al-Daghri, Nasser M.; Alkharfy, Khalid M.; Al-Othman, Abdulaziz; Yakout, Sobhy M.; Al-Saleh, Yousef; Fouda, Mona; Sabico, Shaun. 2013. "Effect of Non-Pharmacologic Vitamin D Status Correction on Circulating Bone Markers in Healthy Overweight and Obese Saudis" Molecules 18, no. 9: 10671-10680. https://doi.org/10.3390/molecules180910671

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