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Molecules 2013, 18(9), 10108-10121; https://doi.org/10.3390/molecules180910108

Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis

1
Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, Madrid 28049, Spain
2
Division of Chemistry and Environmental Science, Faculty of Science and Engineering, Manchester Metropolitan University, John Dalton Extension, Oxford Road, Manchester M1 5GD, UK
3
Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, Alicante 03080, Spain
*
Authors to whom correspondence should be addressed.
Received: 16 July 2013 / Revised: 9 August 2013 / Accepted: 15 August 2013 / Published: 22 August 2013
(This article belongs to the Special Issue Palladium Catalysts)
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Abstract

The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations. Thus, the asymmetric a-allylation of carbonyl compounds, a-fluorination of acyl derivatives, decarboxylative protonation of β-dicarbonyl compounds, cyclization reactions of alkynyl carbonyl compounds and β-functionalization of aldehydes have been efficiently achieved employing this double-catalytic methodology. View Full-Text
Keywords: palladium; organocatalysis; asymmetric synthesis; dual activation; tandem reaction; allylation; fluorination; decarboxylative protonation palladium; organocatalysis; asymmetric synthesis; dual activation; tandem reaction; allylation; fluorination; decarboxylative protonation
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Fernández-Ibañez, M.Á.; Maciá, B.; Alonso, D.A.; Pastor, I.M. Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis. Molecules 2013, 18, 10108-10121.

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