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Open AccessArticle

Perfluoroalkanesulfonamide Organocatalysts for Asymmetric Conjugate Additions of Branched Aldehydes to Vinyl Sulfones

1
Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
2
Gifu Pharmaceutical University 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(12), 14529-14542; https://doi.org/10.3390/molecules181214529
Received: 30 October 2013 / Revised: 20 November 2013 / Accepted: 21 November 2013 / Published: 25 November 2013
(This article belongs to the Special Issue Dynamic Stereochemistry)
Asymmetric conjugate additions of branched aldehydes to vinyl sulfones promoted by sulfonamide organocatalyst 6 or 7 have been developed, allowing facile synthesis of the corresponding adducts with all-carbon quaternary stereocenters in excellent yields with up to 95% ee. View Full-Text
Keywords: organocatalyst; sulfonamide; vinyl sulfone; conjugate addition; quaternary stereocenters; fluorous organocatalyst; sulfonamide; vinyl sulfone; conjugate addition; quaternary stereocenters; fluorous
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Nakashima, K.; Murahashi, M.; Yuasa, H.; Ina, M.; Tada, N.; Itoh, A.; Hirashima, S.-I.; Koseki, Y.; Miura, T. Perfluoroalkanesulfonamide Organocatalysts for Asymmetric Conjugate Additions of Branched Aldehydes to Vinyl Sulfones. Molecules 2013, 18, 14529-14542.

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