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NMR Study on Small Proteins from Helicobacter pylori for Antibiotic Target Discovery: A Review

Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
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Molecules 2013, 18(11), 13410-13424; https://doi.org/10.3390/molecules181113410
Received: 21 June 2013 / Revised: 24 October 2013 / Accepted: 27 October 2013 / Published: 30 October 2013
(This article belongs to the Special Issue NMR of Proteins and Small Biomolecules)
Due to the widespread and increasing appearance of antibiotic resistance, a new strategy is needed for developing novel antibiotics. Especially, there are no specific antibiotics for Helicobacter pylori (H. pylori). H. pylori are bacteria that live in the stomach and are related to many serious gastric problems such as peptic ulcers, chronic gastritis, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Because of its importance as a human pathogen, it’s worth studying the structure and function of the proteins from H. pylori. After the sequencing of the H. pylori strain 26695 in 1997, more than 1,600 genes were identified from H. pylori. Until now, the structures of 334 proteins from H. pylori have been determined. Among them, 309 structures were determined by X-ray crystallography and 25 structures by Nuclear Magnetic Resonance (NMR), respectively. Overall, the structures of large proteins were determined by X-ray crystallography and those of small proteins by NMR. In our lab, we have studied the structural and functional characteristics of small proteins from H. pylori. In this review, 25 NMR structures of H. pylori proteins will be introduced and their structure-function relationships will be discussed. View Full-Text
Keywords: Helicobacter pylori; antimicrobial peptides (AMPs); antibiotics; nuclear magnetic resonance (NMR); structure-activity relationship (SAR) Helicobacter pylori; antimicrobial peptides (AMPs); antibiotics; nuclear magnetic resonance (NMR); structure-activity relationship (SAR)
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Kang, S.-J.; Kim, D.-H.; Lee, B.-J. NMR Study on Small Proteins from Helicobacter pylori for Antibiotic Target Discovery: A Review. Molecules 2013, 18, 13410-13424.

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