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Open AccessArticle

N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)

1
Chemistry Department, Faculty of Science and Mathematic, University of Pendidikan Sultan Idris, Tg. Malim, Perak, Malaysia
2
Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
3
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan
4
Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
*
Author to whom correspondence should be addressed.
Molecules 2011, 16(4), 3402-3409; https://doi.org/10.3390/molecules16043402
Received: 2 March 2011 / Revised: 12 April 2011 / Accepted: 18 April 2011 / Published: 20 April 2011
A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural elucidation was performed via spectral methods, notably 1D- and 2D-NMR, UV, IR, and HRFABMS. The vasorelaxation activity of compound 1 has been studied. View Full-Text
Keywords: Alseodaphne perakensis; Lauraceae; aporphine alkaloid Alseodaphne perakensis; Lauraceae; aporphine alkaloid
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MDPI and ACS Style

Nafiah, M.A.; Mukhtar, M.R.; Omar, H.; Ahmad, K.; Morita, H.; Litaudon, M.; Awang, K.; Hadi, A.H.A. N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae). Molecules 2011, 16, 3402-3409. https://doi.org/10.3390/molecules16043402

AMA Style

Nafiah MA, Mukhtar MR, Omar H, Ahmad K, Morita H, Litaudon M, Awang K, Hadi AHA. N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae). Molecules. 2011; 16(4):3402-3409. https://doi.org/10.3390/molecules16043402

Chicago/Turabian Style

Nafiah, Mohd Azlan; Mukhtar, Mat Ropi; Omar, Hanita; Ahmad, Kartini; Morita, Hiroshi; Litaudon, Marc; Awang, Khalijah; Hadi, A. Hamid A. 2011. "N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)" Molecules 16, no. 4: 3402-3409. https://doi.org/10.3390/molecules16043402

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