The conventional reaction yield evaluation for radioisotope production is not sufficient to set up the optimal conditions for producing radionuclide products of the desired radiochemical quality. Alternatively, the specific radioactivity (SA) assessment, dealing with the relationship between the affecting factors and the inherent properties of the target and impurities, offers a way to optimally perform the irradiation for production of the best quality radioisotopes for various applications, especially for targeting radiopharmaceutical preparation. Neutron-capture characteristics, target impurity, side nuclear reactions, target burn-up and post-irradiation processing/cooling time are the main parameters affecting the SA of the radioisotope product. These parameters have been incorporated into the format of mathematical equations for the reaction yield and SA assessment. As a method demonstration, the SA assessment of 177
Lu produced based on two different reactions, 176
Yb (n,γ) 177
Lu, were performed. The irradiation time required for achieving a maximum yield and maximum SA value was evaluated for production based on the 176
reaction. The effect of several factors (such as elemental Lu and isotopic impurities) on the 177
Lu SA degradation was evaluated for production based on the 176
Yb (n,γ) 177
Lu reaction. The method of SA assessment of a mixture of several radioactive sources was developed for the radioisotope produced in a reactor from different targets.