Next Article in Journal
Two New Chroman Derivations from the Endophytic Penicillium sp. DCS523
Next Article in Special Issue
Locked and Unlocked Nucleosides in Functional Nucleic Acids
Previous Article in Journal
Bioassay-Guided Isolation of an Anti-Ulcer Compound, Tagitinin C, from Tithonia diversifolia: Role of Nitric Oxide, Prostaglandins and Sulfhydryls
Article Menu

Export Article

Open AccessReview
Molecules 2011, 16(1), 675-685;

The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis

Working Group of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, CZ-61265 Brno, Czech Republic
Author to whom correspondence should be addressed.
Received: 20 December 2010 / Revised: 4 January 2011 / Accepted: 17 January 2011 / Published: 17 January 2011
(This article belongs to the Special Issue Nucleoside Analogues)
Full-Text   |   PDF [121 KB, uploaded 18 June 2014]


The review summarizes data evaluating the role of adenosine receptor signaling in murine hematopoietic functions. The studies carried out utilized either non-selective activation of adenosine receptors induced by elevation of extracellular adenosine or by administration of synthetic adenosine analogs having various proportions of selectivity for a particular receptor. Numerous studies have described stimulatory effects of non-selective activation of adenosine receptors, manifested as enhancement of proliferation of cells at various levels of the hematopoietic hierarchy. Subsequent experimental approaches, considering the hematopoiesis-modulating action of adenosine receptor agonists with a high level of selectivity to individual adenosine receptor subtypes, have revealed differential effects of various adenosine analogs. Whereas selective activation of A1 receptors has resulted in suppression of proliferation of hematopoietic progenitor and precursor cells, that of A3 receptors has led to stimulated cell proliferation in these cell compartments. Thus, A1 and A3 receptors have been found to play a homeostatic role in suppressed and regenerating hematopoiesis. Selective activation of adenosine A3 receptors has been found to act curatively under conditions of drug- and radiation-induced myelosuppression. The findings in these and further research areas will be summarized and mechanisms of hematopoiesis-modulating action of adenosine receptor agonists will be discussed. View Full-Text
Keywords: adenosine receptors; hematopoiesis; myelosuppression adenosine receptors; hematopoiesis; myelosuppression
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Hofer, M.; Pospisil, M.; Weiterova, L.; Hoferova, Z. The Role of Adenosine Receptor Agonists in Regulation of Hematopoiesis. Molecules 2011, 16, 675-685.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top